{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:04Z","timestamp":1790873764514,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute Of Postgraduate Medical Education and Research","doi-asserted-by":"publisher","award":["JIP\/Res\/Intra-DM-MCH\/2016-17"],"award-info":[{"award-number":["JIP\/Res\/Intra-DM-MCH\/2016-17"]}],"id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CEFIPRA\/IFCPAR","award":["IFC\/A\/5103-I\/2014\/639"],"award-info":[{"award-number":["IFC\/A\/5103-I\/2014\/639"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The prevalence of various immunological biomarkers in neuropsychiatric systemic lupus erythematosus (NPSLE) differs among various patients with varied neuropsychiatric manifestations and different populations. We studied the prevalence of these biomarkers; especially the neuron specific autoantibodies in patients with systemic lupus erythematosus (SLE) and compared them among patients with and without neuropsychiatric involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This is a comparative cross-sectional study conducted in a tertiary care hospital in South India. The prevalence of immunological biomarkers including complement levels, systemic and brain specific autoantibodies (anti-myelin antibody, anti\u2013myelin oligodendrocyte glycoprotein and anti\u2013myelin-associated glycoprotein antibody) were assessed and compared among those with and without NPSLE and with different NPSLE manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 522 SLE patients were enrolled in the study. The mean age of the study participants was 28.5\u2009\u00b1\u20098.8 years and 93.5% were women. Neuropsychiatric manifestations were seen in 167 (32%) patients. Seizure was the most common neuropsychiatric manifestation seen in 41.3%, followed by psychosis (18.6%), mood disorder (16.8%), stroke (10.8%), mononeuropathy (10.2%), headache (9.6%), acute confusional state (6.6%) and aseptic meningitis (5.4%). Patients with NPSLE had a higher SLE disease activity index score. Most of the autoantibodies, that is anticardiolipin antibody (aCL), anti\u2013\u03b22 glycoprotein 1 antibody (\u03b22GP1), lupus anticoagulant (LA), anti-nucleosome, anti\u2013ribosomal P, anti-Ro52, anti-Ro60 and anti-La, were seen in higher proportion in the NPSLE group, although the difference failed to reach statistical significance. On subgroup analysis, psychosis was significantly higher in patients with anti-ribosomal P positivity than without (11.8% versus 4.1%, p.0.007; odds ratio (OR) 3.1, confidence interval (CI) 1.4\u20136.8), while stroke had a higher proportion among those with positive b2GP1 IgG (6.3% versus 1.8%, p.0.03; OR 3.6, CI 1.2\u201311.0). A higher proportion of demyelination was seen among the LA positive than the negative (10.3% versus 0.2%, p.0.03; OR 5.39, CI 1.15\u201324.17) and anti\u2013myelin oligodendrocyte glycoprotein in mood disorder (14.3% versus 3.4%, p\u2009=\u20090.03; OR 4.66, CI 1.13\u201319.13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No single biomarker correlated with NPSLE. Among different NPSLE manifestations, the prevalence of IgG \u03b22GP1 in stroke, LA in demyelination, anti\u2013ribosomal P in psychosis and anti\u2013myelin oligodendrocyte glycoprotein in mood disorder were higher. Further studies on the pathogenic mechanisms underlying NPSLE and its different manifestations may help us to identify better biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203320908940","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T02:15:30Z","timestamp":1582856130000},"page":"413-420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India"],"prefix":"10.1177","volume":"29","author":[{"given":"G","family":"Seth","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Aakash Healthcare Super Speciality Hospital, Dwarka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sundaresh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Mariaselvam","sequence":"additional","affiliation":[{"name":"INSERM U955, Psychiatrie Translationnelle, Institut Mondor de Recherche Biom\u00e9dicale, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Kumar","sequence":"additional","affiliation":[{"name":"Knowledge Integration and Translation Platform, Center for Health Research and Development, Society for Applied Studies, Kalu Sarai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K G","family":"Chengappa","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Adarsh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Tamouza","sequence":"additional","affiliation":[{"name":"INSERM U955, Psychiatrie Translationnelle, Institut Mondor de Recherche Biom\u00e9dicale, Cr\u00e9teil, France"},{"name":"Fondation FondaMental, Cr\u00e9teil, France"},{"name":"AP-HP, DHU PePSY, Department of Psychiatry, H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-7725","authenticated-orcid":false,"given":"VS","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"bibr1-0961203320908940","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200209"},{"key":"bibr2-0961203320908940","doi-asserted-by":"crossref","unstructured":"Osio-Salido E, Manapat-Reyes H. Epidemiology of systemic lupus erythematosus in Asia. 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Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: Results from an international inception cohort study.\n                      Arthritis Rheum\n                      2008; 58: 843\u2013853.","DOI":"10.1002\/art.23218"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203320908940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203320908940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203320908940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:21:55Z","timestamp":1777677715000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203320908940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/0961203320908940"],"URL":"https:\/\/doi.org\/10.1177\/0961203320908940","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]}}}