{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:35:16Z","timestamp":1790714116744,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH","award":["Autoimmunity Center of Excellence grants AI082724"],"award-info":[{"award-number":["Autoimmunity Center of Excellence grants AI082724"]}]},{"name":"NIH","award":["medical scientist training program grant T32HD0070"],"award-info":[{"award-number":["medical scientist training program grant T32HD0070"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tubulointerstitial inflammation (TII) in lupus nephritis is associated with a worse prognosis. Vimentin, a filamental antigen, is commonly targeted by in situ activated B-cells in TII. The prognostic importance of high serum anti-vimentin antibodies (AVAs) in lupus nephritis and their relationship with common lupus autoantibody specificities is unknown. Herein we investigated associations between AVA isotypes, other autoantibodies, and response to mycophenolate mofetil (MMF) in the presence or absence of rituximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Translational Research Initiative in the Department of Medicine (TRIDOM) cross-sectional cohort of 99 lupus patients was assayed for IgG-, IgA- and IgM- AVAs, lupus-associated and rheumatoid arthritis-associated antibodies, and hierarchically clustered. Serum from baseline, 26 and 52 weeks from 132 Lupus Nephritis Assessment with Rituximab (LUNAR) trial enrolled lupus nephritis patients was also analysed and correlated with renal function up to week 78.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In TRIDOM, AVAs, especially IgM AVAs, clustered with IgG anti-dsDNA and away from anti-Sm and -RNP and rheumatoid arthritis-associated antibodies. In LUNAR at baseline, AVAs correlated weakly with anti-dsDNA and more strongly with anticardiolipin titers. Regardless of treatment, IgG-, but not IgM- or IgA-, AVAs were higher at week 52 than at baseline. In contrast, anti-dsDNA titers declined, regardless of therapeutic regime. High IgG AVA titers at entry predicted less response to therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AVAs, especially IgG AVAs, are unique in distribution and response to therapy compared with other commonly measured autoantibody specificities. Furthermore, high-titer IgG AVAs identify lupus nephritis patients resistant to conventional therapies. These data suggest that AVAs represent an independent class of prognostic autoantibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203320913606","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T01:20:23Z","timestamp":1585272023000},"page":"569-577","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-4038","authenticated-orcid":false,"given":"Andrew J","family":"Kinloch","sequence":"first","affiliation":[{"name":"Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Section of Rheumatology and Department of Medicine, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew 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Knapp Center for Lupus and Immunology Research, University of Chicago, Section of Rheumatology and Department of Medicine, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard L","family":"Dragone","sequence":"additional","affiliation":[{"name":"Early Development, Infectious Disease, The Janssen Pharmaceutical Companies of Johnson & Johnson, South San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirit","family":"Mor Vaknin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Legendre","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Markovitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K","family":"Okoreeh","sequence":"additional","affiliation":[{"name":"Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Section of Rheumatology and Department of Medicine, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Townsend","sequence":"additional","affiliation":[{"name":"Biomarker Discovery OMNI, Genentech Research & Early Development, South San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R","family":"Clark","sequence":"additional","affiliation":[{"name":"Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Section of Rheumatology and Department of Medicine, Chicago, USA"},{"name":"University of Chicago, Section of Rheumatology and Department of Medicine, Chicago, 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