{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:24:00Z","timestamp":1778199840788,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Catastrophic antiphospholipid syndrome (CAPS) is a rare condition characterized by multiple thromboses affecting mainly small vessels in a short period of time in patients with antiphospholipid antibodies. A high suspicion index is mandatory in order to initiate rapidly aggressive immunomodulatory therapy to avoid a very poor prognosis. Systemic lupus erythematosus (SLE) is often associated with antiphospholipid syndrome, with a worse outcome when the catastrophic features occur. We report the case of a 64-year-old woman with a clinical debut of SLE who presented concomitantly with CAPS with several thrombosis affecting the kidney, spleen and bilateral limbs with blue toe syndrome in both legs. Furthermore, she presented with aortitis, with a malaise and myalgias and general syndrome (asthenia, hyporexia and mild weight loss). Fortunately, she had a good response to multi-target combination therapy (anticoagulants, corticosteroids, hydroxychloroquine, intravenous immunoglobulins, plasma exchange and rituximab). Here, we discuss the association between aortitis and CAPS secondary to SLE, and review the literature regarding similar conditions.<\/jats:p>","DOI":"10.1177\/0961203320931173","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:47:37Z","timestamp":1591750057000},"page":"1126-1129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Aortitis in the setting of catastrophic antiphospholipid syndrome in a patient with systemic lupus erythematosus"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-9523","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"},{"name":"Unidad de Enfermedades Sist\u00e9micas Autoinmunes y Minoritarias, Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"L\u00f3pez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"},{"name":"Unidad de Enfermedades Sist\u00e9micas Autoinmunes y Minoritarias, Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Redondo","sequence":"additional","affiliation":[{"name":"Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Patier","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"},{"name":"Unidad de Enfermedades Sist\u00e9micas Autoinmunes y Minoritarias, Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Masso","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Tenorio","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grisel Starita","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmina","family":"Sarhane","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Mart\u00ednez","family":"Lacalzada","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Manzano","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares, IRYCIS, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"bibr1-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705454"},{"key":"bibr2-0961203320931173","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.17.03324-9"},{"key":"bibr3-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312436866"},{"key":"bibr4-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:25:1:61"},{"key":"bibr5-0961203320931173","doi-asserted-by":"crossref","unstructured":"Legault K, Schunemann H, Hillis C, et\u00a0al. McMaster RARE\u2013Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome.\n                      J Thromb Haemost.\n                      Epub ahead of print 7 June 2018. DOI: 10.1111\/jth.14192.","DOI":"10.1111\/jth.14192"},{"key":"bibr6-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key082"},{"key":"bibr7-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.05.004"},{"key":"bibr8-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.02.002"},{"key":"bibr9-0961203320931173","first-page":"346","volume":"34","author":"Bayraktar UD","year":"2007","journal-title":"J Rheumatol"},{"key":"bibr10-0961203320931173","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316678672"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203320931173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203320931173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203320931173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:22:19Z","timestamp":1777677739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203320931173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/0961203320931173"],"URL":"https:\/\/doi.org\/10.1177\/0961203320931173","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]}}}