{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:07:20Z","timestamp":1777928840325,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To delineate laboratory-confirmed bloodstream infection (LCBI), analyze risk factors for its occurrence and predictors for its short-term mortality in systemic lupus erythematosus (SLE) patients. Methods A single center, retrospective, case-controlled study was performed in 159 SLE patients (2013\u20132019) to identify risk factors of LCBI by comparing patients with LCBI (n\u2009=\u200939) to those without infection (n\u2009=\u2009120). The predictors associated with 30-day mortality in LCBI patients were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether 40 bacteria strains were isolated in 39 LCBI patients with a predominance of the gram-negative bacilli (24 strains, 60.0%). Escherichia coli and Staphylococcus aureus were the leading Gram-negative and Gram-positive microorganisms, respectively. Occurrence of LCBI was independently predicted by: SLE disease duration &gt;4\u2009years, SLEDAI score &gt;4 points, glucocorticoids dose &gt;7.5\u2009mg\/d and the previous or concomitant occurrence of autoimmune hemolytic anemia (AIHA) or thrombotic microangiopathy (TMA). Based on the identified risk factors, we developed a matrix model for the risk of future LCBI. The 30-day mortality (39 cases) was 23.1% and healthcare-associated LCBI was a predictor for 30-day mortality in SLE patients compared with community-acquired LCBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Longer duration, higher disease activity and glucocorticoids dose, and occurrence of AIHA or TMA were risk factors of LCBI in SLE and its poor short-term prognosis may attribute to healthcare-associated LCBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203320948964","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T02:53:53Z","timestamp":1598324033000},"page":"1520-1527","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Laboratory-confirmed bloodstream infection in systemic lupus erythematosus: Risk profiling and short-term mortality"],"prefix":"10.1177","volume":"29","author":[{"given":"Man","family":"Wang","sequence":"first","affiliation":[{"name":"Rheumatology and Immunology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology Department, Peking University First Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-2829","authenticated-orcid":false,"given":"Xiaopei","family":"Yang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianfang","family":"Li","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, 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