{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:48:33Z","timestamp":1787615313960,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the ultrasound findings of the nail plate and nail bed in systemic lupus erythematosus (SLE) and its association with nail dystrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-two SLE patients, 36 patients with osteoarthritis (OA) and 20 healthy individuals were studied. High-frequency linear ultrasound was performed in nails of the second to fifth fingers in all participants. Disease activity (SLEDAI-2K index), accrued organ damage (SLICC\/ACR index), autoantibody profile, and Raynaud\u2019s phenomenon were also assessed in SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nail bed thickness in SLE patients was higher than in healthy individuals (1.25\u2009\u00b1\u20090.31\u2009mm vs 1.17\u2009\u00b1\u20090.29\u2009mm; P\u2009=\u20090.01) but lower than in OA (1.39\u2009\u00b1\u20090.37\u2009mm; P\u2009&lt;\u20090.001), while nail plate thickness was similar among groups. Nail dystrophy was found more frequently in SLE and OA than in healthy individuals. SLE patients with nail dystrophy were older than their counterparts with no dystrophy (39.4\u2009\u00b1\u200910.4\u2009years vs 27.8\u2009\u00b1\u20095.6\u2009years; P\u2009=\u20090.004), although nail dystrophy showed no association with SLICC\/ACR, SLEDAI-2K, nail bed vascularity, or autoantibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nail bed in SLE patients is thicker than in healthy individuals but thinner than in OA patients. Nail dystrophy in SLE is associated with advanced age, but not with accrued organ damage, disease activity, Raynaud's phenomenon, or DIP synovitis assessed by ultrasound.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203320988609","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T05:29:27Z","timestamp":1611120567000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasound characterization of the nail bed in patients with systemic lupus erythematosus"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-3770","authenticated-orcid":false,"given":"Diana","family":"Ferrusquia-Toriz","sequence":"first","affiliation":[{"name":"Hospital \u00c1ngeles del Pedregal, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hern\u00e1ndez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Musculoskeletal Ultrasound Laboratory, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-5732","authenticated-orcid":false,"given":"Luis M","family":"Amezcua-Guerra","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Ventura-R\u00edos","sequence":"additional","affiliation":[{"name":"Musculoskeletal Ultrasound Laboratory, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Higuera-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The American British Cowdray Hospital, Mexico City, Mexico"},{"name":"Department of Rheumatology, General Hospital No. 8, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C","family":"Lozada-Navarro","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital Faro del Mayab\/Christus Muguerza, M\u00e9rida Yucat\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis H","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"779","article-title":"Evaluation of nail abnormalities","volume":"85","author":"Tully AS","year":"2012","unstructured":"Tully AS, Trayes KP, Studdiford JD. 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