{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:08:11Z","timestamp":1777928891348,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease characterized by antibody production against a myriad of autoantigens. Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder, triggered by FMF-associated point genes mutations. It has been hypothesized that the two conditions rarely coexist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to examine the proportions of FMF among SLE patients compared with the general population without SLE. We hypothesized that the proportion of FMF among SLE patients might be higher than the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To conduct this cross-sectional study, data of adult patients with a physician diagnosis of SLE were retrieved from Clalit Health Services database, the largest Health Maintenance Organization in Israel, serving 4,400,000 members. Chi-square and T-test was used for univariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population included 4,886 SLE patients and 24,430 age and sex matched controls. Within the SLE group we detected a significantly higher proportion of FMF patients compared with non-SLE controls (0.68% and 0.21% respectively; p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study indicated that FMF is more prevalent in an Israeli population of SLE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033211004726","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T02:36:19Z","timestamp":1617330979000},"page":"1094-1099","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The coexistence of familial Mediterranean fever (FMF) in systemic lupus erythematosus (SLE) patients \u2013 A cross sectional study"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8236-1587","authenticated-orcid":false,"given":"Tamar Laytman","family":"Klein","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"},{"name":"Sheba Medical Center, Internal Medicine B, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Tiosano","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"},{"name":"Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafit","family":"Gilboa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Occupational Therapy, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"},{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clalit Health Services, Quality Measurements and Research, Chief Physician\u2019s Office, Tel-Aviv, Israel"},{"name":"Faculty of Health Sciences, Siaal Research Center for Family Medicine and Primary Care, Ben Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Amital","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"},{"name":"Sheba Medical Center, Internal Medicine B, Tel-Aviv, Israel"},{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Tel-Aviv University, Tel Aviv, Israel"},{"name":"Faculty of Health Sciences, Siaal Research Center for Family Medicine and Primary Care, Ben Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"bibr1-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"bibr2-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key335"},{"key":"bibr3-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1561-8"},{"key":"bibr4-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2018.08.014"},{"key":"bibr5-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.10.011"},{"key":"bibr6-09612033211004726","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.809096"},{"key":"bibr7-09612033211004726","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090687"},{"key":"bibr8-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315627872"},{"key":"bibr9-09612033211004726","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3197"},{"key":"bibr10-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089449"},{"key":"bibr11-09612033211004726","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3102"},{"key":"bibr12-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089403"},{"key":"bibr13-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3477-5"},{"key":"bibr14-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.02.135"},{"key":"bibr15-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12929"},{"key":"bibr16-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.027037"},{"key":"bibr17-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez410"},{"key":"bibr18-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312441048"},{"key":"bibr19-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04420-7"},{"key":"bibr20-09612033211004726","doi-asserted-by":"crossref","unstructured":"Erer B, Cosan F, Oku B, et\u00a0al. MEFV gene variations in patients with systemic lupus erythematosus.\n                      Mod Rheumatol\n                      2013.","DOI":"10.1007\/s10165-013-0848-5"},{"key":"bibr21-09612033211004726","doi-asserted-by":"publisher","DOI":"10.3390\/genes11010110"},{"key":"bibr22-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.018"},{"key":"bibr23-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.003"},{"key":"bibr24-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550313"},{"key":"bibr25-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1002\/art.24458"},{"key":"bibr26-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"bibr27-09612033211004726","unstructured":"Wofsy M. Clinical features of systemic lupus erythematosus. In:\n                      Kelley and Firestein's Textbook of Rheumatology\n                      . Philadelphia, USA, pp.1345\u201367.e3."},{"key":"bibr28-09612033211004726","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000152370.84628.0c"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033211004726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033211004726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033211004726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:23:37Z","timestamp":1777677817000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033211004726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1177\/09612033211004726"],"URL":"https:\/\/doi.org\/10.1177\/09612033211004726","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}