{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:07:50Z","timestamp":1777928870543,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Factors related to presentation of neuropsychiatric (NP) SLE manifestations, early in the course of the disease, and during follow up have not been clearly established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify disease and non-disease related factors associated with NP manifestations in early SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 1193 patients from the GLADEL inception cohort free of NP involvement at cohort entry. We evaluated the association of demographic, clinical and laboratory data with NP involvement during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical methods<\/jats:title>\n                    <jats:p>Independent factors associated with NP involvement were identified using a multivariable Cox regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Factors independently associated with NP manifestations were: mestizo ethnicity (HR 1.701, 95% CI 1.282\u20132.258, p\u2009=\u20090.0002), myalgias\/myositis (HR 1.832, 95% CI 1.335\u20132.515, p\u2009=\u20090.0002), pneumonitis (HR 2.476, 95% CI 1.085\u20135.648, p\u2009=\u20090.0312), shrinking lung (HR 2.428, 95% CI 1.074\u20135.493, p\u2009=\u20090.0331) and hemolytic anemia (HR 1.629, 95% CI 1.130\u20132.347, p\u2009=\u20090.0089). Longer disease duration at cohort entry (13 to 24\u2009months) was associated with a lower risk of developing NP manifestations (HR 0.642, 95% CI 0.441\u20130.934, p\u2009=\u20090.0206).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with myalgias\/myositis, pneumonitis, shrinking lung and hemolytic anemia are at higher risk of NP involvement, whereas longer disease duration at cohort entry is associated with a lower risk of developing NP involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033211020364","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T04:05:39Z","timestamp":1622779539000},"page":"1481-1491","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors associated with neuropsychiatric involvement in Latin American patients with systemic lupus erythematosus"],"prefix":"10.1177","volume":"30","author":[{"given":"Leonor A","family":"Barile-Fabris","sequence":"first","affiliation":[{"name":"Hospital \u00c1ngeles del Pedregal, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-1159","authenticated-orcid":false,"given":"Hilda","family":"Fragoso-Loyo","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda y Reumatolog\u00eda, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Salvador Zubir\u00e1n, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Wojdyla","sequence":"additional","affiliation":[{"name":"GLADEL consultant, Rosario, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-2755","authenticated-orcid":false,"given":"Rosana","family":"Quintana","sequence":"additional","affiliation":[{"name":"Grupo Oro\u00f1o - Centro Regional de Enfermedades Autoinmunes y Reum\u00e1ticas (GO-CREAR), Rosario, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-929X","authenticated-orcid":false,"given":"Guillermo J","family":"Pons-Estel","sequence":"additional","affiliation":[{"name":"Grupo Oro\u00f1o - Centro Regional de Enfermedades Autoinmunes y Reum\u00e1ticas (GO-CREAR), Rosario, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis J","family":"Catoggio","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Reumatolog\u00eda, Servicio de Cl\u00ednica M\u00e9dica, Hospital Italiano de Buenos Aires, Instituto Universitario Escuela de Medicina y Fundaci\u00f3n Dr. Pedro M. Catoggio para el Progreso de la Reumatolog\u00eda, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes A","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, HIGA General San Mart\u00edn, La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Saurit","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital Privado Universitario de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-7291","authenticated-orcid":false,"given":"Cristina","family":"Drenkard","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Emory School of Medicine, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-4681","authenticated-orcid":false,"given":"Eloisa","family":"Bonfa","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F","family":"Borba","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Sato","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paul, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao C","family":"Tavares Brenol","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilzio A","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Reumatologia, Departamento de Clinica Medica, Facultad de Medicina, Hospital das Cl\u00ednicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian T","family":"Lavras Costallat","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Ci\u00eancias Medicas da UNICAMP, Universidade Estadual de Campinas, Campinas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Guibert Toledano","sequence":"additional","affiliation":[{"name":"Servicio Nacional de Reumatolog\u00eda, Centro de Investigaciones M\u00e9dico-Quir\u00fargicas (CIMEQ), La Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4790-1258","authenticated-orcid":false,"given":"Loreto","family":"Massardo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencia, Centro de Biolog\u00eda Celular y Biomedicina, Universidad San Sebasti\u00e1n, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Neira","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Reumatolog\u00eda, Hospital del Salvador, Universidad de Chile, Unidad de Reumatolog\u00eda, Cl\u00ednica Alemana de Santiago, Facultad de Medicina Cl\u00ednica Alemana, Universidad del Desarrollo, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario H","family":"Cardiel","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cl\u00ednica de Morelia, SC, Morelia, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-3138","authenticated-orcid":false,"given":"Mary Carmen","family":"Amigo","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Centro M\u00e9dico ABC, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Garc\u00eda De La Torre","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, CEIBAC, SC, Guadalajara, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis H","family":"Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo M","family":"Acevedo V\u00e1squez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Servicio de Reumatolog\u00eda. Cl\u00ednica San Felipe, Jes\u00fas Mar\u00eda, Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Chac\u00f3n-Diaz","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Policl\u00ednica M\u00e9ndez Gim\u00f3n, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda H","family":"Esteva-Spinetti","sequence":"additional","affiliation":[{"name":"Unidad de Reumatolog\u00eda, Hospital Central de San Crist\u00f3bal, San Crist\u00f3bal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-9175","authenticated-orcid":false,"given":"Graciela S","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA"},{"name":"Department of Medicine, School of Medicine, Universidad Peruana Cayetano, Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo A","family":"Pons-Estel","sequence":"additional","affiliation":[{"name":"Grupo Oro\u00f1o - Centro Regional de Enfermedades Autoinmunes y Reum\u00e1ticas (GO-CREAR), Rosario, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of GLADEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"bibr1-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.62"},{"key":"bibr2-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"bibr3-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.8.1214"},{"key":"bibr4-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)45:5<419::AID-ART360>3.0.CO;2-X"},{"key":"bibr5-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/art.22305"},{"key":"bibr6-09612033211020364","first-page":"2156","volume":"31","author":"Hanly JG","year":"2004","journal-title":"J Rheumatol"},{"key":"bibr7-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.106351"},{"key":"bibr8-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu384"},{"key":"bibr9-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2797::AID-ART467>3.0.CO;2-9"},{"key":"bibr10-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh384"},{"key":"bibr11-09612033211020364","first-page":"76","volume":"34","author":"Fragoso-Loyo HE","year":"2007","journal-title":"J Rheumatol"},{"key":"bibr12-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/art.23566"},{"key":"bibr13-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000104742.42401.e2"},{"key":"bibr14-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"bibr15-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr16-09612033211020364","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr17-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"bibr18-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.03.011"},{"key":"bibr19-09612033211020364","first-page":"55","volume":"30","author":"Chiewthanakul P","year":"2012","journal-title":"Asian Pac J Allergy Immunol"},{"key":"bibr20-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197607000-00004"},{"key":"bibr21-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.3.169"},{"key":"bibr22-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148502"},{"key":"bibr23-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80188-0"},{"key":"bibr24-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210301"},{"key":"bibr25-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000165959.98370.D5"},{"key":"bibr26-09612033211020364","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314520843"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033211020364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033211020364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033211020364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:23:52Z","timestamp":1777677832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033211020364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,4]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/09612033211020364"],"URL":"https:\/\/doi.org\/10.1177\/09612033211020364","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,4]]}}}