{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:16:10Z","timestamp":1792113370055,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers in Turkey were enrolled in the study. LLDAS-50 was defined as encountering LLDAS for at least 50% of the observation time. According to the achievement of LLDAS-50, clinical features, immunological profiles, and treatments of patients with jSLE have been revealed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LLDAS of any duration was achieved by 82% of the cohort. Although only 10.8% of the patients achieved remission, 68.9% reached LLDAS-50. A significant difference was found between patients who reached LLDAS-50 and those who did not, in terms of the time to reach low-dose corticosteroid treatment ( p = 0.002), the presence of subacute cutaneous findings ( p = 0.007), and the presence of proteinuria ( p = 0.002). Both of the groups were under similar treatment approaches. However, the number of patients being treated with corticosteroids at the last visit was found to be significantly higher in patients who achieved LLDAS-50 ( p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeting LLDAS in jSLE, even with long-term, low-dose corticosteroid use, seems to be an achievable goal in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033211054399","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T10:58:09Z","timestamp":1635764289000},"page":"2144-2150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Low disease activity state in juvenile-onset systemic lupus erythematosus"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-0228","authenticated-orcid":false,"given":"Kubra","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Goztepe Prof. Dr Suleyman Yalc\u0131n City Hospital, Istanbul Medeniyet University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-5692","authenticated-orcid":false,"given":"Sen\u011ful","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-4575","authenticated-orcid":false,"given":"Ayse","family":"Tanatar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul University, Faculty of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-8553","authenticated-orcid":false,"given":"Esra","family":"Baglan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Dr Sami Ulus Maternity and Child Health and Diseases Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-6309","authenticated-orcid":false,"given":"Gulcin","family":"Yener Otar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Sanl\u0131urfa Research and Training Hospital, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-7076","authenticated-orcid":false,"given":"Gulsah","family":"Kavrul Kayaalp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul University, Faculty of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-0055","authenticated-orcid":false,"given":"Serife Gul","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9801-925X","authenticated-orcid":false,"given":"Ferhat","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-3068","authenticated-orcid":false,"given":"Hafize Emine","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-4595","authenticated-orcid":false,"given":"Semanur","family":"Ozdel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Dr Sami Ulus Maternity and Child Health and Diseases Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-6406","authenticated-orcid":false,"given":"Mustafa","family":"Cakan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-7387","authenticated-orcid":false,"given":"Nuray","family":"Aktay Ayaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul University, Faculty of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-5644","authenticated-orcid":false,"given":"Betul","family":"Sozeri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PeRA-Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"bibr1-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2019.108274"},{"key":"bibr2-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311416694"},{"key":"bibr3-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.05.001"},{"key":"bibr4-09612033211054399","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160340"},{"key":"bibr5-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212104"},{"key":"bibr6-09612033211054399","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131137"},{"key":"bibr7-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207726"},{"key":"bibr8-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215089"},{"key":"bibr9-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211613"},{"key":"bibr10-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/art.40571"},{"key":"bibr11-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew377"},{"key":"bibr12-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23867"},{"key":"bibr13-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2017-000234"},{"key":"bibr14-09612033211054399","doi-asserted-by":"publisher","DOI":"10.14744\/nci.2020.25826"},{"key":"bibr15-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"bibr16-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"issue":"2","key":"bibr17-09612033211054399","first-page":"288","volume":"29","author":"Gladman DD","journal-title":"J Rheumatology"},{"key":"bibr18-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/art.22048"},{"key":"bibr19-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/art.34410"},{"key":"bibr20-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644333"},{"key":"bibr21-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1163-2"},{"key":"bibr22-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319886028"},{"key":"bibr23-09612033211054399","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100007"},{"key":"bibr24-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216303"},{"key":"bibr25-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20176"},{"key":"bibr26-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202322"},{"key":"bibr27-09612033211054399","doi-asserted-by":"publisher","DOI":"10.1002\/art.27300"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033211054399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033211054399","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033211054399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:24:21Z","timestamp":1777677861000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033211054399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":27,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/09612033211054399"],"URL":"https:\/\/doi.org\/10.1177\/09612033211054399","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]}}}