{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:28:28Z","timestamp":1791638908048,"version":"4.3.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pregnant women with SLE have higher probabilities of maternal complications. SLE during pregnancy has alternating patterns of remission and flare-ups; however, most pregnant SLE patients tend to worsen with associated poor obstetric and perinatal outcomes. This study aimed to describe obstetric outcomes in pregnant women with SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was performed between 2011 and 2020 at a highly complex referral health center in Cali, Colombia. Pregnant women with a diagnosis of SLE were included. Demographic, clinical, and laboratory features and obstetric and fetal outcomes, including intensive care unit (ICU) characteristics, were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-eight pregnant women with SLE were included. The median age was 29 (25\u201333.7) years. The SLE diagnosis was made before pregnancy in 38 (79.1%) patients, with a median disease duration of 46 (12\u201384) months. Thirteen (27.1%) patients had lupus nephritis. Preterm labor (34, 70.8%), preeclampsia (25, 52%), and preterm rupture of membranes (10, 20.8%) were the most common obstetric complications. A relationship between a greater systemic lupus erythematosus pregnancy disease activity index (SLEPDAI) and the development of hypertensive disorders during pregnancy was established (preeclampsia = p &lt; 0.0366; eclampsia = p &lt; 0.0153). A relationship was identified between lupus nephritis (LN) and eclampsia ( p &lt; 0.01), preterm labor ( p &lt; 0.045), and placental abruption ( p &lt; 0.01). Seventeen (35.4%) patients required ICU admission; 52.9% of them were due to AID activity, 17.6% for cardiovascular damage, 11.7% for septic shock, and 5.8% for acute kidney failure. Fetal survival was 89.5% ( N = 43\/48). Among the live births, two (4.2%) newborns were diagnosed with neonatal lupus, and two (4.2%) were diagnosed with congenital heart block. One maternal death was registered due to preeclampsia and intraventricular hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to describe SLE during pregnancy in Colombia. SLE was the most prevalent AID in this cohort, and complications included preterm labor, preeclampsia, and postpartum hemorrhage. A higher SLEPDAI and lupus nephritis predicted adverse maternal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033211061478","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T14:38:16Z","timestamp":1638887896000},"page":"2310-2317","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Systemic erythematosus lupus and pregnancy outcomes in a Colombian cohort"],"prefix":"10.1177","volume":"30","author":[{"given":"Valeria","family":"Erazo-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Nieto-Aristiz\u00e1bal","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian C","family":"Aragon","sequence":"additional","affiliation":[{"name":"CIRAT: Centro de Investigaci\u00f3n en Reumatolog\u00eda, Universidad Icesi, Autoinmunidad y Medicina Traslacional, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Andrea","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia"},{"name":"CIRAT: Centro de Investigaci\u00f3n en Reumatolog\u00eda, Universidad Icesi, Autoinmunidad y Medicina Traslacional, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-4218","authenticated-orcid":false,"given":"Gabriel J","family":"Tob\u00f3n","sequence":"additional","affiliation":[{"name":"CIRAT: Centro de Investigaci\u00f3n en Reumatolog\u00eda, Universidad Icesi, Autoinmunidad y Medicina Traslacional, Cali, Colombia"},{"name":"Unidad de Reumatolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Arango","sequence":"additional","affiliation":[{"name":"Unidad de Gineco-obstetricia, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Echeverri","sequence":"additional","affiliation":[{"name":"Unidad de Reumatolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-8447","authenticated-orcid":false,"given":"David","family":"Aguirre-Valencia","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia"},{"name":"Unidad de Reumatolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali, 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