{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:31:28Z","timestamp":1793309488758,"version":"4.5.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"fluid research grant from Christian Medical College, Vellore"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) prevents pneumocystis jirovecii infection in SLE on immunosuppression. Its role in preventing other major infections in immuno suppressed SLE patients is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A non-concurrent cohort study was conducted on patients of SLE fulfilling SLICC and\/or ACR 1997 criteria, who received tapering dose of steroid starting with \u22650.5\u2009mg\/kg\/day of prednisolone or equivalent dose of deflazacort and mycophenolate mofetil \u22651\u2009g\/day (or equivalent dose of mycophenolate sodium) at least for the preceding 1\u2009year. Interviewing patients &amp; documenting relevant data from hospital electronic Medical records (EMR), followed by comparison of Incidence densities of major infections between those on prophylactic Trimethoprim 160\u2009mg\u2009+\u2009Sulfamethoxazole 800\u2009mg and those not on it, was done by student \u2018t\u2019 test. Multivariate logistic regression was performed for independent risk of any major infection between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 228 patients, 162 did not receive TMP-SMX prophylaxis, and 66 had received. The incidence density of major infection was found to be significantly lower in TMP-SMX group (1.25 per 100 person year) as compared to those not on TMP-SMX group (11.201 per 100 person year); P\u2009&lt;\u20090.001 (95% CI 0.027 \u2013 0.449) and odds ratio of 0.03 (CI 0 \u2013 0.24).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cotrimoxazole prophylaxis in SLE patients on immunosuppression prevents major infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203321995238","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:49:08Z","timestamp":1614214148000},"page":"893-900","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic lupus erythematosus on immunosuppressants: A non-concurrent cohort study"],"prefix":"10.1177","volume":"30","author":[{"given":"Salil A","family":"Ganu","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India"},{"name":"Department of Clinical Immunology and Rheumatology, Amrita Institute of Medical sciences, Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish J","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambily","family":"Nadaraj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-0942","authenticated-orcid":false,"given":"Debashish","family":"Danda","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211796"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607043350103"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39070"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008213030804"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080879"},{"key":"e_1_3_2_7_2","unstructured":"Sample Size Calculator. 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