{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:09:16Z","timestamp":1777928956904,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>(1) To assess the clinical utility of the adjusted global antiphospholipid syndrome score (aGAPSS) to predict new obstetric events during follow-up in primary obstetric antiphospholipid syndrome (POAPS) patients under standard-of-care treatment (SC) based on the use of low-dose aspirin (LDA) + heparin and (2) to study the risk of a first thrombotic event and to evaluate whether stratification according to this score could help to identify POAPS patients who would benefit from long-term thromboprophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective, multicentre study. 169 women with POAPS were evaluated for the presence of a new obstetric event and\/or a first thrombotic event during follow-up [time period: 2008\u20132020, median: 7\u00a0years (6\u201312\u00a0years)]. The outcomes of 107 pregnancies from these POAPS patients with SC were studied to evaluate relapses. Simple and multivariable logistic regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regarding obstetric morbidity, only triple positivity for antiphospholipid antibodies (aPLs) [OR = 8.462 (95% CI: 2.732\u201326.210); p &lt; 0.0001] was found to be a strong risk factor independently associated with treatment failure. On the other hand, triple positivity for aPLs [OR=10.44 (95% CI: 2.161\u201350.469), p = 0.004] and an aGAPSS \u22657 [OR = 1.621 (95% CI: 1.198\u20132.193), p = 0.002] were independent risk factors associated with a first thrombotic event. LDA was marginally associated with a decrease in the risk of thrombosis only in patients with aGAPSS \u2265 7 ( p = 0.048).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>aGAPSS appears to be useful in predicting the occurrence of a first thrombotic event in POAPS patients, and these stratification of patients could be helpful in selecting patients who would benefit from thromboprophylaxis with LDA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033221078223","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T19:25:21Z","timestamp":1644866721000},"page":"354-362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and therapeutic value of the adjusted Global Antiphospholipid Syndrome Score in primary obstetric antiphospholipid syndrome"],"prefix":"10.1177","volume":"31","author":[{"given":"Sebasti\u00e1n","family":"Udry","sequence":"first","affiliation":[{"name":"Autoimmune, Thrombophilic Diseases and Pregnancy Section, Acute Hospital \u201cDr. Carlos G. Durand\u201d, City of Buenos Aires, Argentina"},{"name":"Haemostasis and Thrombosis Laboratory, Hospital of Infectious Diseases \u201cDr. Francisco J. Mu\u00f1iz\u201d, City of Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Morales","family":"Per\u00e9z","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Althaia Healthcare University Network of Manresa, Systemic Autoimmune Disease Unit, Manresa, Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Belizna","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Clinique de l\u2019Anjou, Angers, Vascular and Coagulation Department, University Hospital Angers, Angers, France"},{"name":"UMR CNRS 6015, INSERM U1083, University of Angers, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Aranda","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Laboratory, Hospital of Infectious Diseases \u201cDr. Francisco J. Mu\u00f1iz\u201d, City of Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Esteve-Valverde","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Althaia Healthcare University Network of Manresa, Systemic Autoimmune Disease Unit, Manresa, Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Per\u00e9s","family":"Wingeyer","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Laboratory, Hospital of Infectious Diseases \u201cDr. Francisco J. Mu\u00f1iz\u201d, City of Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego S","family":"Fern\u00e1ndez-Romero","sequence":"additional","affiliation":[{"name":"Autoimmune, Thrombophilic Diseases and Pregnancy Section, Acute Hospital \u201cDr. Carlos G. Durand\u201d, City of Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 O","family":"Latino","sequence":"additional","affiliation":[{"name":"Autoimmune, Thrombophilic Diseases and Pregnancy Section, Acute Hospital \u201cDr. Carlos G. Durand\u201d, City of Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"de Larra\u00f1aga","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Laboratory, Hospital of Infectious Diseases \u201cDr. Francisco J. 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