{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:24:55Z","timestamp":1787509495576,"version":"build-2736575974"},"reference-count":61,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from impaired inflammatory responses. Given the role of air pollution on increasing inflammatory mediators, thus, we aimed to systematically review and meta-analyze evidence regarding an association between short-term exposure to air pollution and SLE onset, activity, and hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic databases including Web of Science, PubMed, Scopus, and Embase were searched for all published articles until July 5, 2021. Newcastle Ottawa Scale (NOS) checklist was used to assess the quality of individual studies. Relevant demographic data and the intended results of the selected studies were extracted, and their adjusted risk ratios (RRs) were pooled using random and fixed effect analysis based on the heterogeneity index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Twelve studies were entered in our systematic review, and finally, six publications were enrolled in meta-analysis. Overall, Meta-analysis showed no significant association between an increase of PM\n                      <jats:sub>2.5<\/jats:sub>\n                      on the third day and SLEDAI score with pooled adjusted RR of 1.212 (95% CI, 0,853\u20131.721), p-value = 0.284. However, there was a positive relationship between 6\u00a0days increase of Particulate matter (PM) 2.5 and the systemic lupus erythematosus disease activity Index (SLEDAI) score (pooled adjusted RR 1.112; 95% CI, 1.005\u20131.231), p-value = 0.040. There was no significant association between carbon monoxide (CO), nitrogen dioxide (NO\n                      <jats:sub>2<\/jats:sub>\n                      ), PM\n                      <jats:sub>2.5<\/jats:sub>\n                      , and PM\n                      <jats:sub>10<\/jats:sub>\n                      increase in the air and hospitalization of SLE patients with pooled RR of 1.021 (95% CI, 0,986\u20131.1.057), p-value = 0.249, 1.034 (95% CI, 0.996\u20131.068); p-value = 0.079, 1.042 (95% CI, 0.994\u20131.092); p-value = 0.084 and 1.004 (95% CI, 0.996\u20131.013); p-value = 0.323, respectively. Also, analysis showed a significant relation between ozone (O\n                      <jats:sub>3<\/jats:sub>\n                      ) increase and hospitalization with a pooled RR of 1.076 (95% CI, 1.009\u20131.147); p-value = 0.025. Finally, analysis of SO\n                      <jats:sub>2<\/jats:sub>\n                      increase and risk of hospitalization demonstrated no significant relationship with the pooled RR of 1.011; (95% CI, 0.962\u20131.062), p-value = 0.0.671.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings prove that PM\n                      <jats:sub>2.5<\/jats:sub>\n                      was associated with increased SLE risk. We also showed that only O\n                      <jats:sub>3<\/jats:sub>\n                      was associated with increased hospital admissions of SLE patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033221127569","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T07:01:07Z","timestamp":1663830067000},"page":"1606-1618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of air pollution on systemic lupus erythematosus: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-1774","authenticated-orcid":false,"given":"Arash Akhavan","family":"Rezayat","sequence":"first","affiliation":[{"name":"Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Student Research Committee, Mashhad University of 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