{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:42Z","timestamp":1777929042237,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Headache, often migrainous, is common in patients with antiphospholipid antibodies, whether or not they meet Sydney criteria for a definite diagnosis of Hughes syndrome. Migraine may be a harbinger of stroke in this patient population and even refractory migraine may be highly responsive to antithrombotic therapy in this clinical context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To summarize what is known to date about managing this important manifestation of the immune-mediated hypercoagulable Hughes syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We provide a suggested management algorithm for refractory headache in this unique patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most neurologists don\u2019t see or recognize many aPL-positive patients in their practice, so hematologists and rheumatologists who see these patients should recognize that refractory headache may be a manifestation of their immune-mediated hypercoagulable disorder and understand that the potential risks of not addressing this issue may be high.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033231153790","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T03:59:47Z","timestamp":1674878387000},"page":"319-324","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["What you need to know about migraine in Hughes syndrome patients"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-3996","authenticated-orcid":false,"given":"JR","family":"Schofield","sequence":"first","affiliation":[{"name":"Center for Multisystem Disease, Denver, CO, USA"},{"name":"Department of Medicine, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KL","family":"Hassell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"bibr1-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320983913"},{"key":"bibr2-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.5.317"},{"key":"bibr3-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1993.hed3308421.x"},{"key":"bibr4-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106832"},{"key":"bibr5-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1191\/096120301678646119"},{"key":"bibr6-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.2.189"},{"key":"bibr7-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312451336"},{"key":"bibr8-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1989.tb01256.x"},{"key":"bibr9-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1080\/10446670410001670526"},{"key":"bibr10-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04348.x"},{"key":"bibr11-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/head.13044"},{"key":"bibr12-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309358186"},{"key":"bibr13-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205663"},{"key":"bibr14-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.016105"},{"key":"bibr15-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1177\/096120330101001103"},{"key":"bibr16-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3180690af6"},{"key":"bibr17-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.03.003"},{"key":"bibr18-09612033231153790","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.221945"},{"key":"bibr19-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.124"},{"key":"bibr20-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez419"},{"key":"bibr21-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-010-0071-3"},{"key":"bibr22-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12582"},{"key":"bibr23-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12106"},{"key":"bibr24-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.10.1164"},{"key":"bibr25-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204838"},{"key":"bibr26-09612033231153790","doi-asserted-by":"publisher","DOI":"10.7326\/M21-0717"},{"key":"bibr27-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"bibr28-09612033231153790","doi-asserted-by":"publisher","DOI":"10.7326\/M20-6194"},{"key":"bibr29-09612033231153790","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13475"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231153790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033231153790","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231153790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:26:39Z","timestamp":1777677999000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033231153790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,28]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/09612033231153790"],"URL":"https:\/\/doi.org\/10.1177\/09612033231153790","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,28]]}}}