{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:11:54Z","timestamp":1780470714215,"version":"3.54.1"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Pulmonary involvement in childhood-onset systemic lupus erythematosus (cSLE), contributes to significant morbidity and mortality. Manifestations include chronic interstitial pneumonitis, pneumonia, pleuritis, alveolar hemorrhage, and shrinking lung syndrome. However, many patients can be asymptomatic from a respiratory standpoint and still have pulmonary function test (PFT) abnormalities. Our aim is to describe PFT abnormalities in patients with cSLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We completed a retrospective review of 42 patients with cSLE followed at our center. These patients were at least 6 years old (so they could complete PFTs). We collected data from July 2015 to July 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the 42 patients, 10 (23.8%) had abnormal PFTs. These 10 patients had a mean age at diagnosis of 13 \u00b1 2.9 years. Nine were female. One-fifth (20%) self-identified as Hispanic, 20% as Asian, 10% as Black or African American, and the remaining 50% as \u201cOther.\u201d Of the 10, 3 had restrictive disease only, 3 with diffusion impairment only, and 4 with both restrictive lung disease and diffusion impairment. Patients with restrictive patterns had a mean total lung capacity (TLC) of 72.5 \u00b1 5.8 throughout the study period. The average diffusing capacity for carbon monoxide corrected for hemoglobin (DsbHb) among patients with diffusion limitation during the study period was 64.8 \u00b1 8.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The most common PFT abnormalities seen in patients with cSLE are alterations in diffusing capacity as well as restrictive lung disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033231163831","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T08:23:53Z","timestamp":1678695833000},"page":"688-693","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A 5\u2013year follow-up of pulmonary function tests in childhood-onset systemic lupus erythematosus: a single-center retrospective study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-1111","authenticated-orcid":false,"given":"AJ","family":"Altchek","sequence":"first","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-2099","authenticated-orcid":false,"given":"LN","family":"Moorthy","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ramagopal","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Salvant","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LP","family":"Uppaluri","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.045"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(90)90051-G"},{"key":"e_1_3_3_4_2","first-page":"1","article-title":"Pulmonary lesions in childhood onset systemic lupus erythematosus: analysis of 26 cases, and summary of literature","volume":"7","author":"Nadorra RL","year":"1987","unstructured":"Nadorra RL, Landing BH. Pulmonary lesions in childhood onset systemic lupus erythematosus: analysis of 26 cases, and summary of literature. Pediatr Pathol 1987; 7: 1\u201318.","journal-title":"Pediatr Pathol"},{"key":"e_1_3_3_5_2","first-page":"203","article-title":"Pulmonary involvement in patients with childhood-onset systemic lupus erythematosus","volume":"24","author":"Lilleby V","year":"2006","unstructured":"Lilleby V, Aal\u00f8kken TM, Johansen B, et al. Pulmonary involvement in patients with childhood-onset systemic lupus erythematosus. Clin Exp Rheumatol 2006; 24: 203\u2013208.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.4.325"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316629554"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920631"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-1981ST"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_3_3_12_2","first-page":"288","article-title":"Systemic lupus erythematosus disease activity index 2000","volume":"29","author":"Gladman DD","year":"2002","unstructured":"Gladman DD, Iba\u00f1ez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002; 29: 288\u2013291.","journal-title":"J Rheumatol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231163831","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033231163831","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231163831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:26:46Z","timestamp":1777678006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033231163831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1177\/09612033231163831"],"URL":"https:\/\/doi.org\/10.1177\/09612033231163831","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]}}}