{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:11:03Z","timestamp":1788588663754,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M01665X\/1"],"award-info":[{"award-number":["MR\/M01665X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024724","name":"NIHR Manchester Clinical Research Facility","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100024724","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to identify factors associated with a significant reduction in SLE disease activity over 12\u00a0months assessed by the BILAG Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an international SLE cohort, we studied patients from their \u2018inception enrolment\u2019 visit. We also defined an \u2018active disease\u2019 cohort of patients who had active disease similar to that needed for enrolment into clinical trials. Outcomes at 12\u00a0months were; Major Clinical Response (MCR: reduction to classic BILAG C in all domains, steroid dose of \u22647.5\u00a0mg and SLEDAI \u2264 4) and \u2018Improvement\u2019 (reduction to \u22641B score in previously active organs; no new BILAG A\/B; stable or reduced steroid dose; no increase in SLEDAI). Univariate and multivariate logistic regression with Least Absolute Shrinkage and Selection Operator (LASSO) and cross-validation in randomly split samples were used to build prediction models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u2018Inception enrolment\u2019 ( n = 1492) and \u2018active disease\u2019 ( n = 924) patients were studied. Models for MCR performed well (ROC AUC = .777 and .732 in the inception enrolment and active disease cohorts, respectively). Models for Improvement performed poorly (ROC AUC = .574 in the active disease cohort). MCR in both cohorts was associated with anti-malarial use and inversely associated with active disease at baseline (BILAG or SLEDAI) scores, BILAG haematological A\/B scores, higher steroid dose and immunosuppressive use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline predictors of response in SLE can help identify patients in clinic who are less likely to respond to standard therapy. They are also important as stratification factors when designing clinical trials in order to better standardize overall usual care response rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033231183273","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T21:33:44Z","timestamp":1689716024000},"page":"1043-1055","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of British Isles Lupus Assessment Group-based outcomes in patients with systemic lupus erythematosus: Analysis from the Systemic Lupus International Collaborating Clinics Inception Cohort"],"prefix":"10.1177","volume":"32","author":[{"given":"Trixy","family":"David","sequence":"first","affiliation":[{"name":"The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-6443","authenticated-orcid":false,"given":"Caroline","family":"Gordon","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Parker","sequence":"additional","affiliation":[{"name":"The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9514-2455","authenticated-orcid":false,"given":"David","family":"Isenberg","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology, Division of Medicine, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-4404","authenticated-orcid":false,"given":"John A","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK"},{"name":"Rheumatology Department, City Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-500X","authenticated-orcid":false,"given":"Ian N","family":"Bruce","sequence":"additional","affiliation":[{"name":"The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"},{"name":"Centre for Musculoskeletal Research, The University of Manchester, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of The Systemic Lupus International Collaborating Clinics Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"MASTERPLANS Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"bibr1-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091181.93122.55"},{"key":"bibr2-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.04.002"},{"key":"bibr3-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.137"},{"key":"bibr4-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211663"},{"key":"bibr5-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa403"},{"key":"bibr6-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr7-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a068841"},{"key":"bibr8-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1191\/096120300672904669"},{"issue":"2","key":"bibr9-09612033231183273","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr10-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev387"},{"key":"bibr11-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa851"},{"key":"bibr12-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"bibr13-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/art.27233"},{"key":"bibr14-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23509"},{"key":"bibr15-09612033231183273","volume-title":"SF-36 physical & mental health summary scales: a manual for users of version 1","author":"Ware J","year":"2001"},{"key":"bibr16-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"bibr17-09612033231183273","volume-title":"The elements of statistical learning: data mining, inference, and prediction","author":"Hastie T","year":"2006","edition":"2"},{"key":"bibr18-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.04.010"},{"key":"bibr19-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214530"},{"key":"bibr20-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203933"},{"key":"bibr21-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205171"},{"key":"bibr22-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1016\/J.BERH.2017.09.005"},{"key":"bibr23-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.131995"},{"key":"bibr24-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1159\/000438844"},{"key":"bibr25-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"bibr26-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213032"},{"key":"bibr27-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2018-000258"},{"key":"bibr28-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1191\/096120399680411335"},{"key":"bibr29-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh238"},{"key":"bibr30-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/art.21039"},{"key":"bibr31-09612033231183273","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1999-18"},{"key":"bibr32-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11084"},{"issue":"10","key":"bibr33-09612033231183273","first-page":"S4942","volume":"71","author":"Konig M","year":"2019","journal-title":"Arthritis Rheum"},{"key":"bibr34-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068676"},{"issue":"10","key":"bibr35-09612033231183273","first-page":"S3665","volume":"69","author":"Kweon S-M","year":"2017","journal-title":"Arthritis Rheum"},{"key":"bibr36-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.885"},{"key":"bibr37-09612033231183273","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180946"},{"key":"bibr38-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1163-2"},{"key":"bibr39-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2017-000234"},{"key":"bibr40-09612033231183273","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180433"},{"key":"bibr41-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319886028"},{"key":"bibr42-09612033231183273","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086314"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231183273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033231183273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231183273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:27:00Z","timestamp":1777678020000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033231183273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/09612033231183273"],"URL":"https:\/\/doi.org\/10.1177\/09612033231183273","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]}}}