{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:28:30Z","timestamp":1785932910564,"version":"3.56.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is non-organ specific autoimmune disease with mainly skin, joint, and kidney involvement. SLE-related acute lung disease (ALD) is rare, poorly investigated and can lead to acute respiratory failure. We conducted a retrospective study aiming to describe clinical features, treatments and outcome of SLE-related APD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included all patients with SLE and ALD admitted from November 1996 and September 2018 to La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, after exclusion of viral or bacterial lung infection, cardiac failure or any other alternate diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the time of the study, 14 patients with 16 episodes were admitted to our center: female 79%, mean age \u00b1 SD at admission 24 \u00b1 11\u00a0years. ALD was inaugural of the SLE in 70% cases. SLE main organ involvement were: arthritis 93%, skin 79%, serositis 79%, hematological 79%, kidney 64%, neuropsychiatric 36% and cardiac 21%. 11 episodes required ICU admission for a median time of 8\u00a0days. Chest CT-scan revealed mostly basal consolidation and ground-glass opacities. When available, bronchoalveolar lavage mostly revealed a neutrophilic alveolitis with alveolar hemorrhage in 67% cases. Symptomatic respiratory treatments were: oxygen 81%, high-flow nasal canula oxygen 27%, non-invasive ventilation 36%, mechanical ventilation 64% and venovenous extracorporeal membrane oxygenation 18%. SLE-specific treatments were: corticosteroids 100%, cyclophosphamide 56% and plasma exchange 25%. All patients but one survived to ICU and hospital discharge. Two patients had a relapse of SLE-related ALD but none had interstitial lung disease during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus-related acute respiratory failure is a severe event, mostly occurring at SLE onset, typical harboring a basal consolidation pattern on chest CT-scan and alveolar hemorrhage on BAL pathological examination. Mortality in our cohort is lower than previously reported but these results needs to be confirmed in further larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033231188034","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T03:29:40Z","timestamp":1688354980000},"page":"1117-1122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic lupus erythematosus-related acute lung disease"],"prefix":"10.1177","volume":"32","author":[{"given":"F\u00e9licien","family":"Triboulet","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne 2, Centre de R\u00e9f\u00e9rence National Lupus Syst\u00e9mique, Syndrome des Anticorps Anti-Phospholipides et Autres Maladies Auto-Immunes Syst\u00e9miques Rares, Institut E3M, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne 2, Centre de R\u00e9f\u00e9rence National Lupus Syst\u00e9mique, Syndrome des Anticorps Anti-Phospholipides et Autres Maladies Auto-Immunes Syst\u00e9miques Rares, Institut E3M, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"},{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Boussouar","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Imagerie Cardiothoracique, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"H\u00e9kimian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheline","family":"Pha","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne 2, Centre de R\u00e9f\u00e9rence National Lupus Syst\u00e9mique, Syndrome des Anticorps Anti-Phospholipides et Autres Maladies Auto-Immunes Syst\u00e9miques Rares, Institut E3M, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rouvier","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomopathologie, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Mathian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne 2, Centre de R\u00e9f\u00e9rence National Lupus Syst\u00e9mique, Syndrome des Anticorps Anti-Phospholipides et Autres Maladies Auto-Immunes Syst\u00e9miques Rares, Institut E3M, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Quentric","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne 2, Centre de R\u00e9f\u00e9rence National Lupus Syst\u00e9mique, Syndrome des Anticorps Anti-Phospholipides et Autres Maladies Auto-Immunes Syst\u00e9miques Rares, Institut E3M, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"},{"name":"Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Inserm, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Moyon","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne 2, Centre de R\u00e9f\u00e9rence National Lupus Syst\u00e9mique, Syndrome des Anticorps Anti-Phospholipides et Autres Maladies Auto-Immunes Syst\u00e9miques Rares, Institut E3M, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"},{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Combes","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"},{"name":"UMRS_1166-ICAN, Inserm, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Edouard","family":"Luyt","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, Paris, France"},{"name":"UMRS_1166-ICAN, Inserm, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Sorbonne Universit\u00e9, Paris, 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