{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:07Z","timestamp":1777929127063,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pneumocystis jirovecii is an opportunistic fungal organism that can cause fatal pneumonia in immunocompromised individuals. It is a disease associated with CD4+ T cell depletion or high-dose steroids. However, there is increasing evidence that B cell dysfunction may also play a role in this illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 33-year-old female with SLE, who was maintained on belimumab and low-dose prednisone (2.5\u00a0mg daily), presented with progressive cough and shortness of breath. She had been on monthly belimumab and prednisone 2.5\u00a0mg daily for 19\u00a0months, and her CD4 count was &gt;200\/uL, but her CD19+ B cell was &lt;1% due to the belimumab. She developed a persistent cough and progressive dyspnea that did not respond to empiric antibiotic therapy for pneumonia. She went to the hospital for acute worsening of her dyspnea and cough. An extensive workup was performed, including a VATS procedure and surgical biopsy, which gave a definitive diagnosis of PJP. The patient was treated and discharged on trimethoprim-sulfamethoxazole. She made a complete recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our report demonstrates the first confirmed case of pneumocystis jirovecii pneumonia in a patient with B cell depletion due to chronic maintenance therapy with belimumab. Our patient\u2019s diagnosis of PJP was unexpected, given her normal CD4+ count and the use of such a low dose of prednisone. We attribute her susceptibility to PJP infection to her profound B cell depletion in response to her belimumab therapy, supporting previous research indicating the importance of CD4+ T cells and B cells in the protective immune response against PJP. This case may help shape future clinical guidelines concerning PJP prophylaxis, particularly in SLE patients with deficient B lymphocytic activity and B cell depletion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033231192334","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T04:32:52Z","timestamp":1690432372000},"page":"1227-1230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hidden consequences: Uncovering belimumab\u2019s role in the development of\n                    <i>Pneumocystis jirovecii<\/i>\n                    pneumonia in a lupus patient"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-5491","authenticated-orcid":false,"given":"Maria","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital, New Hyde Park, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meggan","family":"Mackay","sequence":"additional","affiliation":[{"name":"Hofstra Northwell School of Medicine, Uniondale, NY, USA"},{"name":"Division of Rheumatology, North Shore University Hospital, New Hyde Park, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-1826","authenticated-orcid":false,"given":"Pranisha","family":"Gautam-Goyal","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital, New Hyde Park, NY, USA"},{"name":"Hofstra Northwell School of Medicine, Uniondale, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Goyal","sequence":"additional","affiliation":[{"name":"Hofstra Northwell School of Medicine, Uniondale, NY, USA"},{"name":"Department of Radiology, North Shore University Hospital, New Hyde Park, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-9579","authenticated-orcid":false,"given":"Praveen Kumar","family":"Vikraman","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital, New Hyde Park, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"bibr1-09612033231192334","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.85930"},{"key":"bibr2-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj148"},{"key":"bibr3-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122525"},{"key":"bibr4-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318777634"},{"key":"bibr5-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205777"},{"key":"bibr6-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13826"},{"issue":"6","key":"bibr7-09612033231192334","first-page":"44S","volume":"38","author":"Harmsen AG","year":"1991","journal-title":"J Protozool"},{"key":"bibr8-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.03099-14"},{"key":"bibr9-09612033231192334","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31829d5017"},{"issue":"4","key":"bibr10-09612033231192334","first-page":"671","volume":"35","author":"Mecoli CA","year":"2017","journal-title":"Clin Exp Rheumatol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231192334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033231192334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231192334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:27:06Z","timestamp":1777678026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033231192334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1177\/09612033231192334"],"URL":"https:\/\/doi.org\/10.1177\/09612033231192334","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]}}}