{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:42:53Z","timestamp":1780929773469,"version":"3.54.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006417","name":"Fundo de Apoio ao Ensino, \u00e0 Pesquisa e Extens\u00e3o, Universidade Estadual de Campinas","doi-asserted-by":"publisher","award":["519.292 (98082-22)"],"award-info":[{"award-number":["519.292 (98082-22)"]}],"id":[{"id":"10.13039\/501100006417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/13552-2"],"award-info":[{"award-number":["2017\/13552-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/14819-8"],"award-info":[{"award-number":["2019\/14819-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/14820-6"],"award-info":[{"award-number":["2019\/14820-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/15231-4"],"award-info":[{"award-number":["2019\/15231-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Systemic lupus erythematosus (SLE) patients report worse health-related quality of life (HRQL), fatigue, anxiety, depression, and sleep quality, when compared to the general population and other chronic diseases. Furthermore, cardiometabolic diseases are highly prevalent in SLE and are also associated with these parameters. Thus, it is plausible to suggest that SLE patients with a high cardiovascular risk may report worse results for these parameters. The aim of the study is to describe HRQL, fatigue, anxiety and depression symptoms, and sleep quality in a sample of SLE patients with a high cardiovascular risk profile (i.e., BMI between 25 and 40\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and\/or dyslipidemia, hypertension, or diabetes). This was a cross-sectional study where patients were assessed for (i) demographic, anthropometric, and disease-related parameters, (ii) HRQL, (iii) fatigue, (iv) anxiety and depression symptoms, and (v) sleep quality. One-hundred patients completed the study; however, only 87 patients were assessed for sleep quality data. Patients averaged 41.7 \u00b1 9\u00a0years, and most patients were classified as overweight\/obese (87%). SF-36 scores for physical and mental components summary were 51.3 \u00b1 9.6 and 54.2 \u00b1 15.6, respectively, with \u201cbodily pain\u201d and \u201crole emotional\u201d presenting the lower scores. The total SLEQOL score was 105.1 \u00b1 42.0, with lower scores reported for \u201cself-image\u201d and \u201cmood.\u201d Fatigue score was 30.8 \u00b1 8.9, and 78% and 93% reported severe symptoms of anxiety and depression, respectively. The average sleep effectiveness was 82.9 \u00b1 6.6%. Sleep latency, total time in bed (TTiB), and total sleep time (TST) were 8.4 \u00b1 8.9, 495.8 \u00b1 79.7, and 409.7 \u00b1 69.9\u00a0min, respectively. Patients reported an average of 17.8 \u00b1 6.2 WE, with 4.5 \u00b1 1.5\u00a0min duration and a WASO of 77.7 \u00b1 36.6\u00a0min. Despite similar HRQL, fatigue, and sleep quality parameters to those reported by other SLE populations, SLE patients with a high cardiovascular risk had a higher prevalence of depression and anxiety. Understanding SLE patients\u2019 quality of life and psychological symptoms is of utmost importance to improve disease management. The findings of this study highlight the need for more intensive and global care regarding mental health when considering a high cardiovascular risk in SLE.\n                  <\/jats:p>","DOI":"10.1177\/09612033231202582","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T06:43:42Z","timestamp":1694501022000},"page":"1287-1295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Quality of life, fatigue, sleep quality, and mental health in systemic lupus erythematosus patients with a high cardiovascular risk profile"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-3128","authenticated-orcid":false,"given":"Bruna","family":"Caruso Mazzolani","sequence":"first","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Infante Smaira","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Mendes Sieczkowska","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Romero","sequence":"additional","affiliation":[{"name":"School of Applied Sciences, Universidade Estadual de Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thain\u00e1","family":"Toledo Ribeiro","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla","family":"Cordeiro Amarante","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-6804","authenticated-orcid":false,"given":"Sandra","family":"Pasoto","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia","family":"de S\u00e1 Pinto","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"},{"name":"Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Rodrigues Lima","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"},{"name":"Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Braga Benatti","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"},{"name":"School of Applied Sciences, Universidade Estadual de Campinas, S\u00e3o Paulo, 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