{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:23Z","timestamp":1777929023870,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Digital gangrene is a rare presenting feature of childhood lupus and only a reported incidence of 1.3%. We describe two cases of pediatric onset systemic lupus erythematosus (SLE), both 16\u00a0years old, presenting with digital gangrene and the successful salvage of the digits after using intravenous cyclophosphamide for immunosuppression and use of intravenous prostaglandin E1 infusions for limb reperfusion. Both of the patients responded exceptionally to the infusions with resolution of gangrene and near-total preservation of the functionality of toes.<\/jats:p>","DOI":"10.1177\/09612033231208850","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T02:38:34Z","timestamp":1698201514000},"page":"1572-1578","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of prostaglandin and cyclophosphamide for pediatric lupus with digital gangrene: Back to safety before hitting the axe!"],"prefix":"10.1177","volume":"32","author":[{"given":"Hritvik","family":"Jain","sequence":"first","affiliation":[{"name":"Intern, Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-5406","authenticated-orcid":false,"given":"Aliza","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences Jodhpur, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-2184","authenticated-orcid":false,"given":"Siyaram","family":"Didel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences Jodhpur, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prawin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences Jodhpur, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuldeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences Jodhpur, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"bibr1-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050310006002"},{"key":"bibr2-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.121"},{"key":"bibr3-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep067"},{"issue":"3","key":"bibr4-09612033231208850","volume":"21","author":"Alghamdi MA","year":"2015","journal-title":"Z.U.M.J"},{"issue":"11","key":"bibr5-09612033231208850","first-page":"1747","volume":"18","author":"Hauptman HW","year":"1991","journal-title":"J Rheumatol"},{"issue":"6","key":"bibr6-09612033231208850","first-page":"393","volume":"58","author":"Yoshikawa Y","year":"1996","journal-title":"Cutis"},{"issue":"13","key":"bibr7-09612033231208850","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0025-7753(04)74287-6","volume":"122","author":"Garc\u00eda Hern\u00e1ndez FJ","year":"2004","journal-title":"Med Clin"},{"key":"bibr8-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016660324"},{"key":"bibr9-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1177\/1708538118816267"},{"key":"bibr10-09612033231208850","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20174163"},{"key":"bibr11-09612033231208850","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.889290"},{"key":"bibr12-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8278275"},{"issue":"11","key":"bibr13-09612033231208850","first-page":"400","volume":"5","author":"Nagar RP","year":"2015","journal-title":"Int J Health Sci Res"},{"key":"bibr14-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.4.335"},{"issue":"1","key":"bibr15-09612033231208850","first-page":"e6667","volume":"12","author":"Alalawi ZM","year":"2020","journal-title":"Cureus"},{"key":"bibr16-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-230869"},{"key":"bibr17-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00120.x"},{"key":"bibr18-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199109000-00024"},{"key":"bibr19-09612033231208850","first-page":"bcr2012006259","volume":"2012","author":"Adelowo O","year":"2012","journal-title":"Case Reports"},{"key":"bibr20-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106643"},{"key":"bibr21-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000678"},{"key":"bibr22-09612033231208850","doi-asserted-by":"publisher","DOI":"10.1080\/03009740310004711"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231208850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033231208850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033231208850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:27:18Z","timestamp":1777678038000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033231208850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":22,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1177\/09612033231208850"],"URL":"https:\/\/doi.org\/10.1177\/09612033231208850","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]}}}