{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:19:10Z","timestamp":1783394350927,"version":"3.54.6"},"reference-count":15,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between patients\u2019 characteristics and disease activity in an Argentine lupus registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study. Disease activity was stratified into: Remission off-treatment: SLEDAI = 0, without prednisone and immunosuppressive drugs. Low disease activity Toronto Cohort (LDA-TC): SLEDAI \u22642, without prednisone or immunosuppressive drugs. Modified lupus low disease activity (mLLDAS): SLEDAI score of \u22644, with no activity in major organ systems and no new features, prednisone of \u226410\u00a0mg\/day and\/or immunosuppressive drugs (maintenance dose) and Active disease: SLEDAI score of &gt;4 and prednisone &gt;10\u00a0mg\/day and immunosuppressive drugs. A descriptive analysis and logistic regression model were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1346 patients were included. Of them, 1.6% achieved remission off steroids, 0.8% LDA-TC, 12.1% mLLDAS and the remaining 85.4% had active disease. Active disease was associated with younger age ( p \u2264 0.001), a shorter time to diagnosis ( p \u2264 0.001), higher frequency of hospitalizations ( p \u2264 0.001), seizures ( p = 0.022), serosal disease ( p \u2264 0.001), nephritis ( p \u2264 0.001), higher SDI ( p \u2264 0.001), greater use of immunosuppressive therapies and higher doses of prednisone compared to those on mLLDAS. In the multivariable analysis, the variables associated with active disease were the presence of pleuritis (OR 2.1, 95% CI 1.2\u20133.9; p = 0.007), persistent proteinuria (OR 2.5, 95% CI 1.2\u20135.5; p \u2264 0.011), nephritis (OR 2.5, 95% CI 1.2\u20135.6; p = .018) and hospitalizations (OR 8.9, 95% CI 5.3\u201316.0; p \u2264 0.001) whereas age at entry into the registry was negatively associated with it (OR 0.9, 95% CI 0.9\u20131.0; p = 0.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Active disease was associated with shorter time to diagnosis, worse outcomes (SDI and hospitalizations) and renal, neurological and serosal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033231209601","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T03:00:35Z","timestamp":1699412435000},"page":"1555-1560","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Active lupus in Argentina: Results of a multicenter and national registry"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-2755","authenticated-orcid":false,"given":"Rosana M","family":"Quintana","sequence":"first","affiliation":[{"name":"Grupo Oro\u00f1o, Centro Regional de Enfermedades Autoinmunes y Reum\u00e1ticas (GO-CREAR), Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-9112","authenticated-orcid":false,"given":"Mercedes","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, HIGA General San Martin, La Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-8335","authenticated-orcid":false,"given":"Lucila","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, HIGA General San Martin, La Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Sanatorio Allende, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Alba","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Bellomio","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital Angel C. Padilla, Tucum\u00e1n, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Roverano","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital J.M. Cullen, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analia Patricia","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital Penna, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Enrique","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Centro M\u00e9dico Mitre, Paran\u00e1, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-9857","authenticated-orcid":false,"given":"Cecilia","family":"Pisoni","sequence":"additional","affiliation":[{"name":"CEMIC, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Spindler","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Centro de Investigaciones M\u00e9dicas Tucum\u00e1n, Tucum\u00e1n, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital Central de Formosa, Formosa, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heber Matias","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital de Alta Complejidad Pte. Juan Domingo Per\u00f3n, Formosa, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Papasidero","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital General de Agudos Dr Enrique Torn\u00fa, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Paniego","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, CePReR, Santa Rosa, La Pampa, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Celina","family":"de la Vega","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, CEIM Investigaciones M\u00e9dicas, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Civit","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital del Carmen, Godoy Cruz, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4878-1603","authenticated-orcid":false,"given":"Luciana","family":"Gonzalez Lucero","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital Angel C. Padilla, Tucum\u00e1n, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria","family":"Martire","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital Italiano de La Plata, La Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Aguila Maldonado","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, HIGA General San Martin, La Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, HIGA Dr Alende, Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Micelli","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Hospital General de Agudos Jos\u00e9 Mar\u00eda Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Nieto","sequence":"additional","affiliation":[{"name":"Hospital Provincial de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretel","family":"Rausch","sequence":"additional","affiliation":[{"name":"Department of Reumatologia, Consultorio Privado, Rio Grande, Tierra del Fuego, Rio Grande, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-9175","authenticated-orcid":false,"given":"Graciela S","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Medicine, Marnix E Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Pons-Estel","sequence":"additional","affiliation":[{"name":"Grupo 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