{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:47:50Z","timestamp":1781970470746,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fund of Fujian Science and Technology Department","award":["2021J01363"],"award-info":[{"award-number":["2021J01363"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the possible role of granulin (GRN) in activating the TLR9-IFN-\u03b1 pathway in renal tubular epithelial cells (RTECs) and explore clues that RTECs regulate the micro-environment of inflammatory response in lupus nephritis (LN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Renal sections from 57 LN patients and 30 non-LN patients were sampled for histological study, and GRN overexpression RTECs were applied for cytological study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the histological study, GRN is highly expressed in LN RTECs with tubulointerstitial inflammation (TII) and well co-localized with TLR9. ROC analysis suggested a potential relationship between GRN expression in RTECs and therapeutic response. Moreover, IFN-\u03b1 also highly expressed in LN RTECs with TII, and the intensity of IFN-\u03b1 is positively correlated with the co-localization intensity of GRN and TLR9. In the cytological study, LN serum, especially serum from LN with TII, activates the expression of TLR9 in RTECs, and GRN engages the interaction of TLR9 to activate the expression of IFN-\u03b1 in RTECs. While TLR9 inhibitors can suppress the expression of IFN-\u03b1 in RTECs, the degree of inhibition is dose-dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The expression of GRN in RTECs is associated with interstitial inflammation and therapeutic response. GRN may mediate the activation of the TLR9-IFN-\u03b1 pathway in RTECs and involve in the micro-environment of inflammatory response in LN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241232575","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:47:50Z","timestamp":1707468470000},"page":"439-449","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Granulin in renal tubular epithelia is associated with interstitial inflammation and activates the TLR9-IFN-\u03b1 pathway in lupus nephritis"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9786-3122","authenticated-orcid":false,"given":"Lanting","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbo","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"bibr1-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2527-0"},{"key":"bibr2-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.023"},{"key":"bibr3-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1002\/art.39594"},{"key":"bibr4-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000319"},{"key":"bibr5-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.05.017"},{"key":"bibr6-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.07.007"},{"key":"bibr7-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20441"},{"key":"bibr8-09612033241232575","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10601016"},{"key":"bibr9-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfx093"},{"key":"bibr10-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.08.007"},{"key":"bibr11-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04909-3"},{"issue":"5","key":"bibr12-09612033241232575","first-page":"265","volume":"5","author":"Celhar T","year":"2014","journal-title":"Front Pharmacol"},{"key":"bibr13-09612033241232575","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002795"},{"key":"bibr14-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-012-2104-8"},{"key":"bibr15-09612033241232575","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.987979"},{"key":"bibr16-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902847R"},{"key":"bibr17-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0588-3"},{"key":"bibr18-09612033241232575","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210391"},{"key":"bibr19-09612033241232575","first-page":"575","volume":"18","author":"Psarras A","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"bibr20-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0386-1"},{"key":"bibr21-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309103054"},{"key":"bibr22-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1002\/art.22524"},{"key":"bibr23-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0996-747"},{"key":"bibr24-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80908-8"},{"key":"bibr25-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42382-4"},{"key":"bibr26-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.20.7912"},{"key":"bibr27-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1580145"},{"key":"bibr28-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800713"},{"key":"bibr29-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.6.8243292"},{"key":"bibr30-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091568"},{"key":"bibr31-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01141-8"},{"key":"bibr32-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.018"},{"key":"bibr33-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511406164"},{"key":"bibr34-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199214"},{"key":"bibr35-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1186\/ar4087"},{"key":"bibr36-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201940"},{"key":"bibr37-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.13"},{"key":"bibr38-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142428"},{"key":"bibr39-09612033241232575","first-page":"485","volume":"5","author":"huang L","year":"2018","journal-title":"Guangxi Medical Journal"},{"key":"bibr40-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.04.001"},{"key":"bibr41-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1151-5"},{"key":"bibr42-09612033241232575","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn257"},{"key":"bibr43-09612033241232575","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091202"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241232575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033241232575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241232575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:27:42Z","timestamp":1777678062000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033241232575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/09612033241232575"],"URL":"https:\/\/doi.org\/10.1177\/09612033241232575","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]}}}