{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:26Z","timestamp":1777929146787,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In 2017, belimumab (BEL) was approved in subcutaneous (SQ) administration. The effectiveness after switching from intravenous (IV) to SQ and patient satisfaction in daily clinical practice has not been studied. During the pandemic, patient follow-up and treatment were significantly affected, and some patients need a change from IV to SQ. Our aim was to evaluate daily clinical practice satisfaction to SQ BEL therapy in patients previously treated IV BEL. We hypothesized that SQ BEL in SLE patients previously treated with IV BEL was similar in effectiveness and conferred higher satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational, multicenter study, conducted in 7 reference centers in Catalonia. We included stable SLE patients (EULAR\/ACR 2019) on treatment with SQ BEL and previous use of IV BEL (at least 3\u00a0months on IV BEL before switching). Since there are no well-validated tools for SQ BEL treatment satisfaction, we used RASQ-SQ, validated in patients with lymphoma who switched from IV Rituximab to SQ treatment, and modified for BEL treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-seven patients were included. The more prevalent clinical manifestations observed were related to the skin and joints and the patients had a mean baseline SLEDAI of 2.96 (SD 2.4) and SLICC score of 0.67 (SD 0.88). The median time from treatment with IV BEL before switching to SQ was 21\u00a0months (range). 84% of patients reported confidence in SQ BEL. 85.2% felt that treatment with SQ BEL was convenient or very convenient. 85% felt they had gained time with the change. 89% would recommend the SQ injection to other patients. Disease activity (mean SLEDAI) and remission rates remain stable after switching. No major new adverse effects were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall satisfaction, satisfaction with via of administration, and satisfaction with the time taken to receive BEL were higher for SQ BEL treatment. A switching SQ strategy is a reasonable alternative for BEL patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241237560","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T11:50:27Z","timestamp":1709725827000},"page":"481-489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Satisfaction and effectiveness of switching from intravenous to subcutaneous belimumab treatment in daily clinical practice"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-8434","authenticated-orcid":false,"given":"Beatriz","family":"Frade-Sosa","sequence":"first","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-0174","authenticated-orcid":false,"given":"Tarek Carlos","family":"Salman-Monte","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Del Mar\/Parc de Salut Mar-IMIM, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Peralta","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Germans Trias I Pujol, Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Vall D'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Magallares","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Santa Creu I Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Heredia","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Mois\u00e8s Broggi, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Sapena","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Riveros-Frutos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Germans Trias I Pujol, Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Oliv\u00e9","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Germans Trias I Pujol, Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Corominas","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Santa Creu I Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Cort\u00e9s-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Vall D'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-702X","authenticated-orcid":false,"given":"Jos\u00e9 A","family":"G\u00f3mez-Puerta","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Faculty of Medicine, University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"bibr1-09612033241237560","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359"},{"key":"bibr2-09612033241237560","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102736"},{"key":"bibr3-09612033241237560","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"bibr4-09612033241237560","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613"},{"key":"bibr5-09612033241237560","unstructured":"FDA. https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm246489.htm."},{"key":"bibr6-09612033241237560","unstructured":"Benlysta | European Medicines Agency. 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