{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:43Z","timestamp":1777929043638,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"SORCOM","award":["Beca SORCOM"],"award-info":[{"award-number":["Beca SORCOM"]}]},{"name":"Europeran university of Madrid","award":["Beca intramural"],"award-info":[{"award-number":["Beca intramural"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effect of subclinical synovitis on the progression of joint disease in a cohort of patients with systemic lupus erythematosus over a mean follow-up of 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal follow-up of 96 patients diagnosed with lupus was performed. All patients were considered clinically free of joint disease or with minimal joint impairment at baseline and were studied through ultrasound study of their dominant hand to assess the prevalence of subclinical synovitis. Now, over 10\u00a0years after we contacted them and reviewed their evolution to determine the impact of had or had not been diagnosed with subclinical synovitis in their current joint condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-one of the 91 reached patients developed clinical progression in their joint manifestations (at least one ordinal degree of worsening). Of these, 23 (74,9%) had demonstrated subclinical synovitis at baseline. In the group of patients who did not progress clinically, 46 (76,6%) did not have this finding at the start of follow-up ( p &lt; .01, OR 9,44 95%CI 3,46\u201325,74). The patients in whom clinical progression was demonstrated had worse combined ultrasound scores than the rest of the patients: 6,41 SD 1,45 vs. 1,15 SD 0,97 ( p &lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The finding of subclinical synovitis in patients with systemic lupus erythematosus is associated with the development of joint disease progression both clinically and ultrasonographically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241240584","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:28:46Z","timestamp":1710548926000},"page":"638-643","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-2294","authenticated-orcid":false,"given":"Carlos A","family":"Guill\u00e9n-Astete","sequence":"first","affiliation":[{"name":"Rheumatology Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"},{"name":"Faculty of Biomedical Sciences and Health, European University of Madrid, Villaviciosa de Od\u00f3n, Madrid, Spain"},{"name":"Rheumatology Unit, HLA Moncloa University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelino","family":"Revenga-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio C","family":"Zea-Mendoza","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E","family":"Brito-Brito","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Zurita-Prada","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, HLA Moncloa University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Urrego-Laur\u00edn","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, HLA Moncloa University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Villalobos-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Ram\u00f3n y Cajal University Hospital, Madrid, 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