{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:26:57Z","timestamp":1789248417045,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"RCC-MSU"},{"name":"DBT-India"},{"name":"DBT- Biotechnology Teaching Program"},{"name":"DBT- BUILDER Program"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Major reason for mortality among systemic lupus erythematosus patients is renal failure due to the deposition of immune complexes in the glomeruli. Being a chronic disease with multiple relapses and remissions across the lifespan, it\u2019s important to know the degree of nephritis for diagnosis as well as the long-term clinical management of the patients. Currently, renal biopsy is being used as the gold standard to diagnose and define the stages of the disease. However, renal biopsy being invasive only provides a localized picture of nephritis, and has the risk of bleeding. Additionally, it is also cost-intensive. Hence, a reliable, non-invasive biomarker is required for lupus nephritis. This study has evaluated extracellular mitochondrial components, including cell-free mitochondria, and cell-free mitochondrial DNA as probable biomarkers of the degree of nephritis. Both showed a significant correlation with proteinuria and protein-creatinine ratio. Our study substantiates their usage as clinical biomarkers of nephritis upon their validation in a larger cohort of lupus nephritis patients and other forms of nephritis. Although the current data suggest using cell-free mitochondria as a biomarker of lupus nephritis is better than the cell-free mitochondrial DNA.<\/jats:p>","DOI":"10.1177\/09612033241247622","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T20:40:30Z","timestamp":1713213630000},"page":"779-786","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Extracellular mitochondrial components as new biomarkers for lupus nephritis"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5239-0632","authenticated-orcid":false,"given":"Sharath","family":"Gowda","sequence":"first","affiliation":[{"name":"Department of Microbiology and Biotechnology Centre, The Maharaja Sayajirao University of Baroda, Vadodara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology Centre, The Maharaja Sayajirao University of Baroda, Vadodara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology Centre, The Maharaja Sayajirao University of Baroda, Vadodara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip Kumar","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Baroda Arthritis & Rheumatism Care Centre, Vadodara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namisha","family":"Patel","sequence":"additional","affiliation":[{"name":"Rheumatology Division, City Clinic, Vadodara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapan","family":"Pandya","sequence":"additional","affiliation":[{"name":"V. 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