{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:59Z","timestamp":1777929059669,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) causes kidney compromise in up to 40% of patients, contributing significantly to morbidity. Lupus nephritis (LN), an early onset manifestation in most patients, is histologically classified into six types, with types III, IV, and V requiring treatment with induction therapies, usually glucocorticoids with mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC). However, up to 60% of patients fail to achieve complete remission, and 27%\u201366% have subsequent flares. There is scarce literature on the superiority of IVC or MMF in the Latin population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A retrospective cohort study of 72 LN patients at a high-complexity hospital in Chile between 2016 and 2021 was conducted. Demographics, urine studies, creatinine levels, complement levels, antibody profiles, biopsy results, and response to treatment were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of the cohort was 29\u00a0years, with women representing 90% of patients. At diagnosis, 87.5% of the patients presented with proteinuria, 55% had haematuria, and 49% had acute kidney injury. The most common LN type was type IV. For induction therapy, half of the patients were treated with IVC, and the other half with MMF. The response to treatment did not differ significantly between the two.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This is one of the few studies to focus on the Latin American population, specifically Chile. These results are consistent with the current understanding of LN treatment. Despite its limitations, this study provides valuable insights into the treatment effectiveness of IVC and MMF in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study did not find significant differences in the clinical response to IVC or MMF at 6\u00a0months. Future prospective studies are required to determine the optimal induction therapy for LN, especially in Latin populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241249574","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T14:48:41Z","timestamp":1713883721000},"page":"769-773","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Induction treatment for lupus nephritis at a high-complexity hospital in Chile"],"prefix":"10.1177","volume":"33","author":[{"given":"Paulina","family":"Ramirez","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Complejo Asistencial Dr S\u00f3tero del R\u00edo, Puente Alto, Chile"},{"name":"Internal Medicine Department, Complejo Asistencial, Dr S\u00f3tero del R\u00edo, Puente Alto, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-4531","authenticated-orcid":false,"given":"Andres","family":"Giglio","sequence":"additional","affiliation":[{"name":"Critical Care Department, Finis Terrae University, Santiago, Chile"},{"name":"Critical Care Department, Cl\u00ednica Las Condes Hospital, Las Condes, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Verdugo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Complejo Asistencial, Dr S\u00f3tero del R\u00edo, Puente Alto, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Complejo Asistencial Dr S\u00f3tero del R\u00edo, Puente Alto, Chile"},{"name":"Internal Medicine Department, Complejo Asistencial, Dr S\u00f3tero del R\u00edo, Puente Alto, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"bibr1-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"bibr2-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"bibr3-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00925-5"},{"key":"bibr4-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218272"},{"key":"bibr5-09612033241249574","first-page":"CD002922","volume":"6","author":"Tunnicliffe DJ","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep346"},{"issue":"1","key":"bibr7-09612033241249574","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-020-00234-1","volume":"7","author":"Kellum JA","year":"2021","journal-title":"Nat Rev Dis Prim"},{"key":"bibr8-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"bibr9-09612033241249574","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05780616"},{"key":"bibr10-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0141-9"},{"key":"bibr11-09612033241249574","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040670"},{"key":"bibr12-09612033241249574","doi-asserted-by":"publisher","DOI":"10.1002\/art.10461"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241249574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033241249574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241249574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:27:56Z","timestamp":1777678076000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033241249574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/09612033241249574"],"URL":"https:\/\/doi.org\/10.1177\/09612033241249574","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}