{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:57:58Z","timestamp":1783792678979,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystemic disease. Monitoring disease activity thoughtout the disease course is important for effective management and assessment of disease outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether the pan-immune inflammation value (PIIV) at diagnosis could predict organ involvement and disease activity in childhood SLE (cSLE) patients after 12\u00a0months of disease onst.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is an observational retrospective multicenter study that comprised cSLE patients seen and followed at the participating centers between January 2010 and December 2022. All patients met the EULAR\/ACR-19 criteria, were immunosuppressive drug-na\u00efve at the time of SLE diagnosis and had a minimal follow-up period of 12\u00a0months. The data included clinical and laboratory findings and disease activity using the SLEDAI-2K. Receiver operating characteristic (ROC) curves were employed to determine the optimal cut-off value of PIIV and assess its predictive potential for disease activity, and organ involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 125 patients (104 female) with a median age of 16.0 (IQR 5.6) years, a median age at disease onset of 10.9 (IQR 3.0) years, and a median disease duration of 4.8 (IQR 5.3) years were included. The most frequent involved organs at diagnosis were hematological (89.6%), musculoskeletal (68.8%), mucocutaneous (63.2%), and renal (58.4%). However, at a 12-month follow-up visit, the most frequent involved organs were renal (40.0%), hematological (39.2%), musculoskeletal (15.2%), and mucocutaneous (10.4%). The median PIIV at diagnosis was 139 (IQR 229.6), while the median SLEDAI was 12 (IQR 6.5) and 3.5 (IQR 7.0) at diagnosis and 12\u00a0months, respectively. An optimal PIIV cut-off of 250 was found to be a predicative for disease activity, with a sensitivity of 45% and a specificity of 86%. The study revealed that the PIIV successfully predicted four systems in our cohort of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our work suggests the PIIV might be a reasonable predictor for organ involvement and disease activity in newly diagnosed cSLE, though further research, particularly larger studies, is required to validate these findings, especially regarding organ involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241275227","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T08:53:02Z","timestamp":1723798382000},"page":"1365-1372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of pan-immune-inflammation value as a predictor of the prognosis of childhood lupus"],"prefix":"10.1177","volume":"33","author":[{"given":"Ali","family":"Alasmari","sequence":"first","affiliation":[{"name":"Pediatric Rheumatology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Aldakhil","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, King Saud Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-2655","authenticated-orcid":false,"given":"Mohammed","family":"Nashawi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emtenan","family":"Basahl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awatif","family":"Abushhaiwia","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Tripoli Children Hospital, Tripoli, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad","family":"Hashad","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Tripoli Children Hospital, Tripoli, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Etayari","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Tripoli Children Hospital, Tripoli, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra","family":"Elfawires","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Tripoli Children Hospital, Tripoli, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khulood Walid","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reima","family":"Bakry","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Maternity and Children Specialized Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujayn","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Fahad University Hospital, Khobar, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"De Vol","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alhanouf","family":"AlSaleem","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-6698","authenticated-orcid":false,"given":"Sulaiman M","family":"Al-Mayouf","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"},{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi 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