{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:42Z","timestamp":1777929222380,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology. All participants met the Systemic Lupus International Collaborating Clinics criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 123 patients, 78 (63.4%) exhibited GIS involvement at the initial SLE diagnosis, whereas the remaining 45 (36.6%) developed GI symptoms after a median duration of 12 (3\u2013140) months. Eighty-two (66.7%) individuals experienced symptoms related to the GI tract, whereas the remaining patients received a diagnosis of GI involvement through laboratory assessments. The predominant initial GIS involvement symptom was abdominal pain, observed in 77 (62.6%) patients, followed by elevated hepatic transaminases in 70 (56.9%), hepatomegaly in 40 (32.5%), diarrhea in 26 (21.1%), and jaundice in 11 (8.9%) patients. The GIS involvement was associated with SLE in 82 (78.6%), while it resulted from drug-related adverse events in 35 (28.5%) patients or comorbidities in 6 (0.5%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GIS involvement should be considered in all childhood onset-SLE patients, especially in the presence of suggestive symptoms or elevated hepatic transaminases. It is also crucial to consider SLE in the differential diagnosis of GIS manifestations in children. Apart from GIS involvement directly associated with SLE, adverse events of drugs should be kept in mind.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241279071","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T12:57:54Z","timestamp":1724677074000},"page":"1358-1364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-3068","authenticated-orcid":false,"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Rheumatology, Kocaeli University, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-2363","authenticated-orcid":false,"given":"Ezgi Deniz","family":"Batu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"\u0130\u015fg\u00fcder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Rheumatology, Dokuz Eyl\u00fcl University, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Rheumatology, Kocaeli University, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Aliyev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esma","family":"Aslan","sequence":"additional","affiliation":[{"name":"Cerrahpa\u015fa Medical Faculty, Department of Pediatric Rheumatology, Istanbul University-Cerrahpa\u015fa, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcmeyra","family":"\u00c7oban","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Umraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vildan","family":"G\u00fcng\u00f6rer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eerife G\u00fcl","family":"Karada\u011f","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Rheumatology, Istanbul University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Kara\u00e7ay\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-3222","authenticated-orcid":false,"given":"Hakan","family":"K\u0131sao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydan","family":"Yeked\u00fcz B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Erciyes University, Kayseri, 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