{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:50Z","timestamp":1777929170904,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vitamin-K antagonists (VKA) are considered the first-line anticoagulants for thrombotic antiphospholipid syndrome (TAPS), particularly with triple positivity or arterial events. However, thrombotic recurrence remains high despite anticoagulation and other clinical issues may arise. Long-term parenteral anticoagulants may therefore be considered, however little is known about the viability of fondaparinux in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We describe the efficacy and safety of long-term fondaparinux for TAPS (&gt;3-months duration) treated at a single centre in the UK. Clinical features and the outcomes of recurrence and bleeding were reviewed using electronic patient records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>46 patients were identified with history of either venous or arterial TAPS and a total 175 patient-years using fondaparinux (median duration 2.7 years\/patient (IQR 1.4\u20134.8)). 43 (93%) had VKA as first-line anticoagulation with a median duration of 6.5 years (IQR 4.0 \u2013 9.8). All patients received fondaparinux as second-to fourth-line anticoagulation. Thrombosis recurrence occurred in 1 (1%) patient (0.6 events\/100-patient years). Major, clinically relevant non-major (CRNM) or minor bleeding occurred in 2 (7%), 5 (10.9%) and 8 (17.4%) patients respectively. Major\/CRNM bleeding rates were 1.1 and 2.9 events\/100-patient-years. Age &gt;65years was associated with bleeding ( p = .047) and concurrent antiplatelets were associated with major\/CRNM bleeding ( p = .011). Logistic regression showed increasing age was associated with bleeding (OR = 1.097, p = .009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We suggest that fondaparinux may be used for TAPS when VKA is not appropriate. Thrombotic recurrence was infrequent, and the number of major bleeding events appeared comparable to conventional therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241285225","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T07:31:38Z","timestamp":1726558298000},"page":"1446-1454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical outcomes of patients receiving long-term fondaparinux for thrombotic antiphospholipid syndrome"],"prefix":"10.1177","volume":"33","author":[{"given":"Buse","family":"Bor","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Aarhus, Aarhus, Denmark"},{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-0486","authenticated-orcid":false,"given":"Andrew J","family":"Doyle","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-3174","authenticated-orcid":false,"given":"John K","family":"Bartoli-Abdou","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"},{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Hackett","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Collings","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"},{"name":"Institute of Pharmaceutical Science, King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Omrani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Foskett","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Wareing","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Young","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A","family":"Breen","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-0774","authenticated-orcid":false,"given":"Beverley J","family":"Hunt","sequence":"additional","affiliation":[{"name":"Centre for Haemostasis and Thrombosis, Guy\u2019s & St Thomas NHS Foundation Trust, London, 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