{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:33:28Z","timestamp":1782862408500,"version":"3.54.5"},"reference-count":10,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune condition characterized by acquired prothrombin (FII) deficiency associated with antiphospholipid syndrome (APS) and life-threatening bleeding. We present the case of a 34-year-old woman with heavy menstrual bleeding (HMB), positive Lupus anticoagulant (LA) test, and high titer anticardiolipin antibodies Immunoglobulin G (ACA IgG) and anti-\u03b22 glycoprotein I antibodies IgG (antiB2GPI IgG). Severe iron deficiency anemia necessitated recurrent blood transfusions and intravenous iron infusions from 2018 to 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In January 2022, she was admitted to our clinic. Von Willebrand disease screening and platelet function analysis (PFA100) were normal. FII and FIX deficiencies were detected, without factor IX inhibitors. Anti-phosphatidylserine\/prothrombin antibodies were confirmed by Padua University lab. To reduce antibody titers and menstrual bleeding, immunosuppressive therapy (Rituximab 375 mg\/m2 weekly \u00d74 weeks) and hormonal therapy (desogestrel 75 mcg\/day) were initiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After 1-year, complete remission of clinical symptoms was achieved, with normalization of FII and FIX values and moderate reduction of aPS\/PT titers, especially IgM isotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241299619","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T08:30:30Z","timestamp":1730795430000},"page":"1611-1614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Rituximab in lupus anticoagulant hypoprothrombinemia syndrome: A case report"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-9331","authenticated-orcid":false,"given":"Jacopo","family":"Agnelli Giacchello","sequence":"first","affiliation":[{"name":"Hemostasis and thrombosis unit, AOU SS Antonio e Biagio e C Arrigo, Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol Francesca","family":"Trincheri","sequence":"additional","affiliation":[{"name":"Analysis laboratory unit, AOU SS Antonio e Biagio e C Arrigo, Alessandria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Sciancalepore","sequence":"additional","affiliation":[{"name":"Hemostasis and thrombosis unit, AOU SS Antonio e Biagio e C Arrigo, Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Contino","sequence":"additional","affiliation":[{"name":"Hemostasis and thrombosis unit, AOU SS Antonio e Biagio e C Arrigo, Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Mario","family":"Santi","sequence":"additional","affiliation":[{"name":"Hemostasis and thrombosis unit, AOU SS Antonio e Biagio e C Arrigo, Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-6071","authenticated-orcid":false,"given":"Vittorio","family":"Pengo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Sciences, Thrombosis Centre, University of Padua School of Medicine, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"bibr1-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V15.2.212.212"},{"key":"bibr2-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"bibr3-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13976"},{"key":"bibr4-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15785"},{"key":"bibr5-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V61.4.684.684"},{"key":"bibr6-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.6.1538.bloodjournal6561538"},{"key":"bibr7-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4127-9"},{"key":"bibr8-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31826b971f"},{"key":"bibr9-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317751853"},{"key":"bibr10-09612033241299619","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019030932"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241299619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033241299619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241299619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:28:27Z","timestamp":1777678107000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033241299619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":10,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/09612033241299619"],"URL":"https:\/\/doi.org\/10.1177\/09612033241299619","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]}}}