{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:10Z","timestamp":1777929190046,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Antinuclear antibodies (ANA) staining patterns can provide useful information in systemic lupus erythematosus (SLE). In our study, we examined the frequency of ANA staining patterns in disease-related features in childhood-onset SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ANA and its staining patterns were assessed in childhood-onset SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred twenty-three patients were included (F\/M = 3\/1). Their median age at diagnosis was 14.3 (11.9-16.1) years. The anti-cell (AC)-4\/5 (fine or large speckled) pattern was the most common nuclear ANA pattern (75.8%), while the AC-19 (dense fine speckled) pattern was the most frequently detected cytoplasmic ANA pattern (13.1%). The AC-4\/5 (fine or large speckled) patterns were notably seen in fever, acute and chronic cutaneous lupus, arthritis, serositis, hematologic involvement, renal involvement, neuropsychiatric involvement, gastrointestinal involvement, and cardiopulmonary involvement (all p &lt; .001). Conversely, the AC-1 (homogeneous) pattern was significantly detected in oral\/nasal ulcers and non-scarring alopecia (both p &lt; .001). Regarding the laboratory features, the AC-4\/5 (fine or large speckled) patterns exhibited a predominant seen in autoimmune hemolytic anemia, leukopenia, thrombocytopenia, elevated ESR and CRP, hypocomplementemia, direct Coombs, anti-Smith (Sm), anti-SSA and SS-B, anti-ribonucleoprotein (RNP), anti-histone, anti-ribosomal P, lupus anticoagulant, anti-cardiolipin immunoglobulin (Ig)M\/IgG, and anti-\u03b22-glycoprotein IgM\/IgG positivities (all p &lt; .001). In contrast, the AC-1 (homogeneous) pattern was detected in anti-double-stranded (ds) DNA and anti-histone positivity (both p &lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed that AC-4\/5 and AC-1 patterns of ANA are frequently detected in many clinical and serological features of childhood-onset SLE patients. However, further studies are needed in larger populations to verify these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241305198","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T20:45:18Z","timestamp":1732740318000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Examination of antinuclear antibody staining patterns and titers in patients with childhood-onset systemic lupus erythematosus"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-8996","authenticated-orcid":false,"given":"Seher","family":"Sener","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-2363","authenticated-orcid":false,"given":"Ezgi Deniz","family":"Batu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Unal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge","family":"Basaran","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Saribas","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcin","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"bibr1-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214436"},{"key":"bibr2-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa831"},{"key":"bibr3-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0480-7"},{"key":"bibr4-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2022.100145"},{"key":"bibr5-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-021-09233-0"},{"key":"bibr6-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad144"},{"key":"bibr7-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-022-00264-1"},{"key":"bibr8-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-020-00925-2"},{"key":"bibr9-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"bibr10-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.69"},{"key":"bibr11-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1002\/art.38365"},{"key":"bibr12-09612033241305198","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.850759"},{"key":"bibr13-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203863"},{"key":"bibr14-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.74"},{"key":"bibr15-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12849"},{"key":"bibr16-09612033241305198","doi-asserted-by":"publisher","DOI":"10.4103\/injr.injr_198_20"},{"key":"bibr17-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcreu.2023.05.003"},{"key":"bibr18-09612033241305198","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003608"},{"issue":"8","key":"bibr19-09612033241305198","first-page":"e43532","volume":"15","author":"Al-Mughales 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