{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:11:14Z","timestamp":1777929074240,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A6A1A03044296"],"award-info":[{"award-number":["2021R1A6A1A03044296"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002460","name":"Chung-Ang University","doi-asserted-by":"publisher","award":["Research Scholarship Grants in 2023"],"award-info":[{"award-number":["Research Scholarship Grants in 2023"]}],"id":[{"id":"10.13039\/501100002460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI19C1202"],"award-info":[{"award-number":["HI19C1202"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the trends in immunomodulator use and pregnancy outcomes among pregnant women with systemic lupus erythematosus (SLE), a condition requiring medication to maintain disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This descriptive study used data from the National Health Information Database in Korea from 2002 to 2018. We included 5,044 pregnancies initiated between 2005 and 2017 in 3,120 SLE patients. Annual trends in SLE therapy, drug utilisation patterns during the preconception and pregnancy periods, and pregnancy outcomes were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pregnancy compatible immunosuppressant (PC-IS) and hydroxychloroquine use during the first trimester were 10.7% and 41.4%, respectively. Most SLE medications exhibited a decline in usage from the preconception period to the first trimester. A prescription rate of 0.9% for pregnancy incompatible immunosuppressants (PIC-IS) was observed during the first trimester, and the incidence of live births, stillbirths, and abortions remained consistent from 2005 to 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Insufficient usage of hydroxychloroquine and PC-IS, along with a reduction in PIC-IS usage primarily during early pregnancy rather than before conception, highlights the unmet need for preconceptional family planning with appropriate medication management strategies in SLE pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241310087","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T09:16:26Z","timestamp":1735982186000},"page":"140-148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Utilisation patterns of immunomodulators and pregnancy outcomes in systemic lupus erythematosus: Insights from Korean national data"],"prefix":"10.1177","volume":"34","author":[{"given":"Yu-Seon","family":"Jung","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chung-Ang University, Seoul, South Korea"},{"name":"Hanyang University Institute for Rheumatology Research, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Hanyang University Institute for Rheumatology Research, Seoul, Korea"},{"name":"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Kyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Hanyang University Institute for Rheumatology Research, Seoul, Korea"},{"name":"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-8939","authenticated-orcid":false,"given":"Yoon-Kyoung","family":"Sung","sequence":"additional","affiliation":[{"name":"Hanyang University Institute for Rheumatology Research, Seoul, Korea"},{"name":"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-112X","authenticated-orcid":false,"given":"Sun-Young","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chung-Ang University, Seoul, South Korea"},{"name":"Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209770"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05496-4"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033221107538"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11447"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002752"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.070367"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24130"},{"key":"e_1_3_6_9_2","first-page":"561","article-title":"Medication use among pregnant women with systemic lupus erythematosus and general population comparators","volume":"56","author":"Palmsten K","year":"2017","unstructured":"Palmsten K, Simard J, Chambers C, et al. Medication use among pregnant women with systemic lupus erythematosus and general population comparators. Rheumatol 2017; 56: 561\u2013569.","journal-title":"Rheumatol"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203321989803"},{"key":"e_1_3_6_11_2","first-page":"799","article-title":"Data resource profile: the national health information database of the national health insurance service in South Korea","volume":"46","author":"Seong S","year":"2017","unstructured":"Seong S, Kim Y, Khang Y, et al. Data resource profile: the national health information database of the national health insurance service in South Korea. 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