{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:43:19Z","timestamp":1784018599130,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,3]]},"abstract":"\n Introduction:<\/jats:bold>\n The pathogenesis for poor kidney outcomes in lupus nephritis (LN) remains uncertain. There is limited evidence on the association between angiotensin-converting enzyme\n (ACE) I\/D<\/jats:italic>\n polymorphism and LN with kidney failure.\n Objectives:<\/jats:bold>\n To determine the distribution of\n ACE I\/D<\/jats:italic>\n alleles and genotypes and the correlation between ACE I\/D polymorphism and kidney outcomes in LN participants.\n Subjects and Methods:<\/jats:bold>\n A cross sectional study was conducted at Cho Ray Hospital (12\/2021-07\/2023). The LN participants were stratified into 3 groups based on the kidney function and kidney replacement therapy (KRT) on admission. The\n ACE I\/D<\/jats:italic>\n polymorphism was identified by the polymerase chain reaction.\n Results:<\/jats:bold>\n Among 208 LN participants, 71 were in group 1 (eGFR > 60), 55 in group 2 (eGFR \u2264 60 without KRT), 82 in group 3 (eGFR \u2264 60 with KRT). The skewed distribution among 3 groups were observed in\n D<\/jats:italic>\n allele (20.4%, 35.5%, 37.2% in group 1, 2, 3, respectively,\n p<\/jats:italic>\n = .003) and\n DD<\/jats:italic>\n genotype (2.8%, 14.6%, 12.2% in group 1, 2, 3, respectively,\n p<\/jats:italic>\n = .005). The\n ID\/DD<\/jats:italic>\n genotypes increased the susceptibility of kidney failure (eGFR \u2264 60 vs eGFR > 60: OR = 8.26 for\n DD<\/jats:italic>\n genotype, OR = 2.31 for\n ID<\/jats:italic>\n genotype) and KRT (KRT vs no KRT: OR = 2.01 for\n ID<\/jats:italic>\n genotype).\n Conclusions:<\/jats:bold>\n The\n D<\/jats:italic>\n allele and\n ID\/DD<\/jats:italic>\n genotypes are linked with the susceptibility of kidney failure in LN participants.\n <\/jats:p>","DOI":"10.1177\/09612033251317346","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T08:49:31Z","timestamp":1738658971000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Insertion\/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis at Cho Ray hospital, Vietnam"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-0799","authenticated-orcid":false,"given":"Anh N. L.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"},{"name":"Nephrology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam"},{"name":"Westmead Applied Research Centre, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh T.","family":"Le","sequence":"additional","affiliation":[{"name":"Molecular Biology Unit, Hematology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W. S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Westmead Applied Research Centre, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Centre for Kidney Research, School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong T. B.","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"},{"name":"Nephrology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114844"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920622"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.33"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13236"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.6.1433-a"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.04.006"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310385163"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30026-1"},{"key":"e_1_3_4_12_2","first-page":"740","volume-title":"Heptinstall's Pathology of the kidney","author":"Laszik ZG","year":"2015","unstructured":"Laszik ZG, Kambham N, Silva FG. Chapter 18: thrombotic microangiopathies. In: Jennette JCOJ, Silva FG, D'Agati VD (eds). Heptinstall's Pathology of the kidney. 7th ed. Pennsylvania, USA: Lippincott Williams & Wilkins, 2015, pp. 740\u2013815.","edition":"7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364179"},{"issue":"7","key":"e_1_3_4_14_2","first-page":"461","article-title":"Angiotensin-converting enzyme gene polymorphism and the clinical pathological features and progression in lupus nephritis","volume":"36","author":"Guan T","year":"1997","unstructured":"Guan T, Liu Z, Chen Z. Angiotensin-converting enzyme gene polymorphism and the clinical pathological features and progression in lupus nephritis. Zhonghua Nei Ke Za Zhi 1997; 36(7): 461\u2013464.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"issue":"3","key":"e_1_3_4_15_2","first-page":"141","article-title":"Association of an insertion polymorphism of angiotensin-converting enzyme gene with the activity of lupus nephritis","volume":"51","author":"Akai Y","year":"1999","unstructured":"Akai Y, Sato H, Iwano M, et al. Association of an insertion polymorphism of angiotensin-converting enzyme gene with the activity of lupus nephritis. Clin Nephrol 1999; 51(3): 141\u2013146.","journal-title":"Clin Nephrol"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1470320312460898"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033251317346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033251317346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033251317346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:28:37Z","timestamp":1777678117000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033251317346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/09612033251317346"],"URL":"https:\/\/doi.org\/10.1177\/09612033251317346","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]}}}