{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:23:27Z","timestamp":1780773807926,"version":"3.54.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Basic Scientific Research Project of Colleges and Universities of Liaoning Province Education Department","award":["No. LJKMZ20221212"],"award-info":[{"award-number":["No. LJKMZ20221212"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the real-world efficacy and safety of telitacicept in Chinese systemic lupus erythematosus (SLE) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-center observational study enrolled 41 SLE patients treated with telitacicept between April 2021 and March 2022. Baseline characteristics and 24-week follow-up clinical outcomes were collected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 41 SLE patients who received telitacicept at least once were included. Compared with baseline (10.0 \u00b1 6.85), SLEDAI-2K scores significantly decreased at 12 weeks (6.25 \u00b1 5.46,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001) and 24 weeks (4.18 \u00b1 4.78,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). The proportion of organ involvement, as assessed by SLEDAI-2K, significantly decreased in skin\/mucosa and musculoskeletal involvement. The mean glucocorticoid dose (prednisone equivalent) was significantly reduced at 12 weeks (14.19 \u00b1 8.88\u00a0mg\/d,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001) and 24 weeks (9.86 \u00b1 4.25\u00a0mg\/d,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .001) compared with baseline (20.87 \u00b1 16.71\u00a0mg\/d). C3 and C4 levels showed an increasing trend. In patients with lupus nephritis, 24-h urinary protein levels significantly reduced from 2.81 \u00b1 3.83\u00a0g\/day at baseline to 1.00 \u00b1 1.32\u00a0g\/day after 24 weeks of treatment (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .005), with a 68.66% decline (IQR, 35.61%, 76.30%). Albumin levels also significantly improved (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .003). Nine treatment-emergent adverse events (TEAEs) were recorded in six patients, all of which were mild and moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real-world study, telitacicept combined with conventional therapy showed good onset efficacy and safety for treating SLE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251332052","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:30:53Z","timestamp":1750818653000},"page":"597-607","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of telitacicept in the treatment of systemic lupus erythematosus: A retrospective real-world study"],"prefix":"10.1177","volume":"34","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Shengjing Hospital of China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Chang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical 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