{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:11:44Z","timestamp":1777929104240,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia","award":["KFU252165"],"award-info":[{"award-number":["KFU252165"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by the production of various autoantibodies and involvement of multiple organ systems, including the eyes. Growing evidence suggests that dysregulation of proteins from the sirtuin family, particularly sirtuin-1 (SIRT1), may play a crucial role in the pathophysiology of SLE, despite its incomplete understanding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate SIRT1 levels and study potential association with keratoconjunctivitis sicca (KCS) in SLE patients in relation to disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted on 42 SLE adult patients and 42 healthy controls. Serum SIRT1 levels were measured using enzyme-linked immunosorbent assay. Disease activity was assessed using the SLE Disease Activity Index (SLEDAI) score. Correlations between SIRT1 levels, KCS and disease activity, were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with SLE had significantly higher SIRT1 levels than healthy controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; \u2009.001). SIRT1 was strongly correlated with disease activity (r = 0.958,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), and albuminuria (r = 0.719,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). Negative correlations were observed between SIRT1 levels and C3 (r = \u22120.843,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), C4 (r = \u22120.861,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), white blood cell count (r = \u22120.616,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001) and platelet count (r = \u22120.534,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). Additionally, Patients with SLE who presented with KCS had significantly higher SIRT1 levels than those without (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). SIRT1 exhibited exceptional diagnostic efficacy in differentiating between Patients with SLE and control subjects, with an AUC of 1 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001) and in identifying KCS in SLE patients, with an AUC of 0.989 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). The multivariable regression model indicated that a lower platelets count (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .034; OR \u22120.014; 95% CI \u22120.026 to \u22120.001) and high SIRT1 levels (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001; OR 0.838; 95% CI 0.678\u20130.998) were independent predictors of disease activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum SIRT1 levels were significantly elevated in patients with SLE and correlated with the presence of KCS and disease activity. SIRT1 may serve as a potential biomarker of eye involvement in SLE, the disease pathogenesis and severity, and its modulation could offer a therapeutic target for the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251349458","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T10:46:36Z","timestamp":1750329996000},"page":"932-942","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sirtuin-1 in systemic lupus erythematosus: Frequency of keratoconjunctivitis sicca and relation to disease activity"],"prefix":"10.1177","volume":"34","author":[{"given":"Eman Ali","family":"Abdallah","sequence":"first","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-891X","authenticated-orcid":false,"given":"Khaled Mohamed Amin","family":"Elzorkany","sequence":"additional","affiliation":[{"name":"King Faisal University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Salem","sequence":"additional","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Elshemy","sequence":"additional","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manar","family":"Dawoud","sequence":"additional","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Khirat","sequence":"additional","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Alsharaky","sequence":"additional","affiliation":[{"name":"Menoufia University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.632383"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223741"},{"key":"e_1_3_5_4_2","volume-title":"Diagnosis and treatment of uveitis","author":"Foster C","year":"2013","unstructured":"Foster C, Vitale A. 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