{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:25Z","timestamp":1777929145048,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["ZIAAR041199"],"award-info":[{"award-number":["ZIAAR041199"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"Intramural Research Program of the National Institute of Nursing Research","doi-asserted-by":"publisher","award":["ZIANR000020"],"award-info":[{"award-number":["ZIANR000020"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Program of the National Institutes of Health Clinical Center","award":["ZIACL060096"],"award-info":[{"award-number":["ZIACL060096"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Fatigue among females with systemic lupus erythematosus (SLE) is commonly reported as the most debilitating symptom. Slower oxygen uptake (VO\n                    <jats:sub>2<\/jats:sub>\n                    ) on-kinetics have been observed among females with SLE, when compared to healthy control individuals. Aerobic exercise training may improve VO\n                    <jats:sub>2<\/jats:sub>\n                    on-kinetics, however, this has not been examined in the SLE population.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To characterize VO\n                      <jats:sub>2<\/jats:sub>\n                      on-kinetics in SLE and examine changes after 12\u00a0weeks of aerobic exercise training (AET).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Females (\n                      <jats:italic>n<\/jats:italic>\n                      = 16; 42 \u00b1 10\u00a0years) with SLE (SELENA-SLEDAI \u2264 4) completed a cardiopulmonary exercise test (CPET) and a constant work rate test (CWRT), before and after participation in supervised vigorous treadmill AET for 12\u00a0weeks. Pulmonary gas exchange, heart rate (HR) and deoxygenation ([HHb]) of the right gastrocnemius muscle were also measured during the CWRT. Model fits for VO\n                      <jats:sub>2<\/jats:sub>\n                      , HR and [HHb] were performed, and a ratio of the increase in [HHb] and VO\n                      <jats:sub>2<\/jats:sub>\n                      were examined in a subset of participants (\n                      <jats:italic>n<\/jats:italic>\n                      = 10). On-kinetic responses of all variables and the [HHb]\/VO\n                      <jats:sub>2<\/jats:sub>\n                      ratio were analyzed before and after AET using paired sample t-tests or Wilcoxon signed-rank tests. Spearman\u2019s rank correlations were used to examine the relationships of VO\n                      <jats:sub>2<\/jats:sub>\n                      on-kinetics and peak CPET variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VO\n                      <jats:sub>2<\/jats:sub>\n                      on-kinetics was faster (mean difference [95% CI],\n                      <jats:italic>p<\/jats:italic>\n                      -value: \u221212.0 s [\u221218.1 to \u22126.0],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001) following AET, and the VO\n                      <jats:sub>2<\/jats:sub>\n                      time constant post-AET was moderate and indirectly related to cardiorespiratory fitness outcomes for peak VO\n                      <jats:sub>2<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      = \u22120.562,\n                      <jats:italic>p<\/jats:italic>\n                      = .024) and peak work rate (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      = \u22120.535,\n                      <jats:italic>p<\/jats:italic>\n                      = .033). The HR on-kinetics was also faster following AET (median difference [95% CI],\n                      <jats:italic>p<\/jats:italic>\n                      -value: \u22126.7 s [\u221230.8 to \u22121.2],\n                      <jats:italic>p<\/jats:italic>\n                      = .022), however a change in the [HHb] time course was unlikely (median difference [95% CI],\n                      <jats:italic>p<\/jats:italic>\n                      -value: \u22121.1 s [\u22123.6 to 23.5],\n                      <jats:italic>p<\/jats:italic>\n                      = .508).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Following supervised exercise training, females with SLE demonstrated faster VO\n                      <jats:sub>2<\/jats:sub>\n                      on-kinetics, which were also related to cardiorespiratory fitness. The faster VO\n                      <jats:sub>2<\/jats:sub>\n                      on-kinetics with exercise training was also accompanied by faster HR on-kinetics, suggesting central circulatory adaptation occurring in these females with SLE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251349464","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:08:46Z","timestamp":1749726526000},"page":"922-931","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["VO\n                    <sub>2<\/sub>\n                    on-kinetics and aerobic exercise training in females with systemic lupus erythematosus"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2635-6506","authenticated-orcid":false,"given":"Zoe","family":"Morris","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA"},{"name":"Tampa General Hospital, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Camarillo","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarfaraz","family":"Hasni","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall E","family":"Keyser","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leighton","family":"Chan","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-739X","authenticated-orcid":false,"given":"Lisa MK","family":"Chin","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.10.007"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key398"},{"key":"e_1_3_5_4_2","first-page":"790724","article-title":"Silent burdens in disease: fatigue and depression in SLE","volume":"2014","author":"Fonseca R","year":"2014","unstructured":"Fonseca R, Bernardes M, Terroso G, et al. 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