{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:59:18Z","timestamp":1778075958078,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"UHCMC","award":["I0159"],"award-info":[{"award-number":["I0159"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with a highly heterogeneous presentation. Thrombocytopenia (TP) is an uncommon manifestation in SLE patients and is often associated with major organ involvement and poor prognosis. In this study, we aimed to evaluate the prevalence of TP in SLE patients and analyze its association with demographic and clinical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized data from the ACR\u2019s Rheumatology Informatics System for Effectiveness (RISE) registry, a large, electronic health record-enabled database that collects data as part of routine clinical care. The study included patients who were \u226518\u00a0years old, had \u22652 SLE diagnostic codes recorded \u226530\u00a0days apart between 2016 and 2022, and had a valid complete blood count (CBC) recorded within 1\u00a0year of the second SLE code. Thrombocytopenia (TP) was classified based on the lowest platelet count within 1\u00a0year of the second SLE code: mild: 100,000\u2013150,000\/\u00b5L, moderate: 50,000\u201399,000\/\u00b5L, and severe: &lt;50,000\/\u00b5L. We reported the frequency of TP by demographic and clinical characteristics. To identify factors associated with moderate-to-severe TP, we employed multi-level logistic regression models, controlling for covariates and accounting for clustering by practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 30,062 patients (91.2% female; mean age: 56\u00a0years, SD: 16). The frequencies of TP and severe TP were 9.3% and 0.5%, respectively. Patients with moderate-to-severe TP had significantly higher frequencies of male sex, African-American and Hispanic ethnicity, lupus nephritis, leukopenia, anemia, hypocomplementemia, anti-dsDNA positivity, end-stage renal disease, thrombosis, hemolytic anemia, antiphospholipid syndrome, and multiple comorbidities compared to other SLE patients. Multivariable logistic regression analysis demonstrated persistent independent associations of sex, race\/ethnicity, multiple comorbidities, positive dsDNA, and hypocomplementemia with an increased risk of moderate-to-severe TP in SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The RISE registry revealed that severe TP was less common in SLE patients from community practice compared to previously reported data from selected tertiary centers. Serologically active SLE, multiple comorbidities, male sex, and non-white race were identified as independent factors associated with TP in this database. Further studies are needed to elucidate the exact mechanisms and clinical significance of TP in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251396277","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:05:06Z","timestamp":1761908706000},"page":"1528-1535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Thrombocytopenia in systemic lupus erythematosus real-world insights from the nationwide RISE database"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-5879","authenticated-orcid":false,"given":"Omer Nuri","family":"Pamuk","sequence":"first","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Schmajuk","sequence":"additional","affiliation":[{"name":"University of California San Francisco"},{"name":"Department of Medicine, Division of Rheumatology, San Francisco VA Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Nighat","family":"Magrey","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01898-7"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223741"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0677-6"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.07.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2023.23069"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102887"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/bz64na"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2014-000078"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033100"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103297"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab925"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261002"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537101003735564"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22376"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313512009"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103721"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23089"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_3_4_20_2","volume-title":"STATA multiple-imputation reference manual release 17","year":"2021","unstructured":"STATA multiple-imputation reference manual release 17. 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