{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:13:24Z","timestamp":1793938404248,"version":"4.8.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Programa Para El Aseguramiento De La Calidad De Los Posgrados (PROAC), Universidad De Guadalajara","award":["SNP 004086-SECIHTI"],"award-info":[{"award-number":["SNP 004086-SECIHTI"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    We aimed to investigate\n                    <jats:italic toggle=\"yes\">in-situ<\/jats:italic>\n                    expression of interleukin IL-17A, IL-21, IL-22, and IL-35 in lupus nephritis (LN).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A cross-sectional study using immunohistochemistry (IHC) in renal biopsy to detect\n                    <jats:italic toggle=\"yes\">in-situ<\/jats:italic>\n                    expression of interleukin IL-17 family and IL-35 from 20 Mexican patients with moderate to severe LN.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    We found predominant expression of IL-17A and IL-21 in the glomerular region. IL-22 was detected in the tubulointerstitium and inflammatory aggregates, notwithstanding IL-21 and IL-35 in fibrotic and atrophic tubules. A positive correlation was found between IL-17A expression in the glomerulus and tubulointerstitium with creatinine, urea, and blood urea nitrogen levels, whereas IL-35 expression decreases in the presence of proteinuria. IL-21 was high in disease activity and severity versus IL-35 that decreased in systemic lupus erythematosus (SLE) disease activity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These findings provide evidence for the compartment-specific expression in LN of Th17-related cytokines and IL-35 in Mexican patients.\n                  <\/jats:p>","DOI":"10.1177\/09612033251405359","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T23:57:59Z","timestamp":1764287879000},"page":"65-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential glomerular expression patterns of Th17-related cytokines in Mexican patients with lupus nephritis"],"prefix":"10.1177","volume":"35","author":[{"given":"Andrea","family":"Aguilar-Vazquez","sequence":"first","affiliation":[{"name":"Universidad de Guadalajara"},{"name":"Secretar\u00eda de Ciencias, Humanidades y Tecnolog\u00edas (SECIHTI)"},{"name":"Nuevo Hospital Civil Dr Juan I. 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