{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:55:45Z","timestamp":1793706945470,"version":"4.6.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018036","name":"Nippon Shinyaku Co., Ltd.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018036","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical Co., Ltd.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>While oral glucocorticoids (GC) have improved the prognosis of lupus nephritis (LN), dose reduction to \u22645.0\u00a0mg\/day is recommended, considering their toxicity. We investigated the real-world prescription status following dose reduction of oral GC after starting initial therapy in patients with LN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the JMDC insurance claims database between May 2016 and March 2023 with the following inclusion criteria: patients with \u22652 LN diagnoses; follow-up for \u226590\u00a0days pre-index and \u2265540\u00a0days post-index; oral GC dose \u226520.0\u00a0mg\/day (prednisolone equivalent) or intravenous glucocorticoid pulse; \u22652 urinalyses, anti-double stranded DNA antibody, and complement tests within 360 days post-index. Descriptive analyses were performed by characterization as dose reduction target (GC \u22645.0\u00a0mg\/day at Day 540) \u2018achieved\u2019 or \u2018non-achieved\u2019 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean oral GC baseline dose for the overall population (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 295) was 36.1\u00a0mg\/day. The two most prescribed immunosuppressants were mycophenolate mofetil (MMF; 41.7%) and tacrolimus (TAC; 16.9%). The proportion of patients with prescribed GC doses \u22645.0\u00a0mg\/day was 1.0% on Day 1 and 48.1% on Day 540. In the achieved and non-achieved groups, the baseline concomitant immunosuppressants were MMF: 51.4% and 32.7% and TAC: 15.5% and 18.3%, respectively, while the proportion of patients with GC \u22647.5\u00a0mg\/day was 31.0% and 12.4% on Day 180, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These real-world administrative data show the actual oral GC prescription status after starting initial LN therapy in Japan. Approximately half of the patients with LN were prescribed GC \u22645.0\u00a0mg\/day within 1.5 years after starting the initial therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251408515","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:39:09Z","timestamp":1768826349000},"page":"129-139","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Real-world glucocorticoid prescription patterns in patients with lupus nephritis: A retrospective study using a healthcare insurance claims database"],"prefix":"10.1177","volume":"35","author":[{"given":"Tatsuya","family":"Atsumi","sequence":"first","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-9012","authenticated-orcid":false,"given":"Hironari","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Saitama Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Murakami","sequence":"additional","affiliation":[{"name":"Nippon Shinyaku Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Nio","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Urakawa","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Fujita Health University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212732"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2024.2360664"},{"key":"e_1_3_7_5_2","unstructured":"Japan Intractable Diseases Information Center. The number of specific stipendiary certificate holders of medical expenses (designation incurable disease). https:\/\/www.nanbyou.or.jp\/entry\/53 (2020 Accessed 05 November 2024)."},{"key":"e_1_3_7_6_2","first-page":"613","article-title":"Long-term safety and effectiveness of tacrolimus in patients with lupus nephritis in Japan: 10-year analysis of the real-world TRUST study","volume":"51","author":"Takeuchi T","year":"2024","unstructured":"Takeuchi T, Wakasugi N, Hashida T, et al. Long-term safety and effectiveness of tacrolimus in patients with lupus nephritis in Japan: 10-year analysis of the real-world TRUST study. J Rheumatol 2024; 51: 613\u2013621.","journal-title":"J Rheumatol"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2022-222435"},{"key":"e_1_3_7_8_2","unstructured":"Atsumi T. 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