{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:59:49Z","timestamp":1784203189404,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neonatal lupus erythematosus (NLE) is a potentially life-threatening condition resulting from the transfer of autoantibodies from the mother to the fetus, with congenital heart block (CHB) its most serious complication. Despite the potential severity, therapeutic strategies remain limited. The objective was to systematically evaluate all registered clinical trials to date for the treatment or prevention of NLE and its cardiac manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the Clinicaltrials.gov database on January 24, 2025, to identify all registered clinical trials for NLE treatments since 1994. This online registration of clinical trials is maintained by the NLM, a division of the National Institutes of Health (NIH), and mandates regular trial updates and timely results reporting. The registry provides specifics on a clinical trial, such as a national clinical trial (NCT) number, current recruitment status, study type, and other important data related to the trial. Principal investigators must submit results within 1\u00a0year of the trial\u2019s primary completion date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three eligible trials for NLE were found on the NLM clinical trials database. One trial reported that hydroxychloroquine treatment reduced the recurrence rate of congenital heart block by more than half, from 18% to 7.4%. The remaining studies explored intravenous immunoglobulin and dexamethasone without posting results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Congenital heart block from NLE was decreased in recurrence by treatment with hydroxychloroquine. However, the scarcity of research towards advancing care for these conditions highlights a major gap in this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251412477","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:31:39Z","timestamp":1766586699000},"page":"189-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Current and future interventions for neonatal lupus: A review of the national library of Medicine\u2019s clinical trials database"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0942-510X","authenticated-orcid":false,"given":"Ashleigh","family":"Buzzell","sequence":"first","affiliation":[{"name":"Office of Medical Student Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7117-0428","authenticated-orcid":false,"given":"Carrson","family":"French","sequence":"additional","affiliation":[{"name":"Office of Medical Student Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Po","sequence":"additional","affiliation":[{"name":"Oklahoma State University Center for Health Sciences and OSU Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Gilstrap","sequence":"additional","affiliation":[{"name":"Oklahoma State University Center for Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah","family":"Hartwell","sequence":"additional","affiliation":[{"name":"Oklahoma State University Center for Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2022.122601"},{"key":"e_1_3_4_3_2","unstructured":"Neonatal Lupus. Cleveland Clinic. https:\/\/my.clevelandclinic.org\/health\/diseases\/neonatal-lupus (accessed 19 December 2024)."},{"key":"e_1_3_4_4_2","first-page":"301274","article-title":"Neonatal lupus erythematosus","volume":"2012","author":"Hon KL","year":"2012","unstructured":"Hon KL, Leung AKC. Neonatal lupus erythematosus. Autoimmune Dis 2012; 2012: 301274.","journal-title":"Autoimmune Dis"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2020-0543"},{"key":"e_1_3_4_6_2","first-page":"CD007058","article-title":"Ultrasound for fetal assessment in early pregnancy","volume":"2015","author":"Whitworth M","year":"2015","unstructured":"Whitworth M, Bricker L, Mullan C. Ultrasound for fetal assessment in early pregnancy. Cochrane Database Syst Rev 2015; 2015: CD007058.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27333"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.05.045"},{"key":"e_1_3_4_9_2","article-title":"Clinical trials registration and results information submission","author":"Health and Human Services Department","unstructured":"Health and Human Services Department. Clinical trials registration and results information submission. Fed Regist. https:\/\/www.federalregister.gov\/d\/2016-22129","journal-title":"Fed Regist"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.02.010"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14132"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.083"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0223"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X211073001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000026"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3565"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22911"},{"key":"e_1_3_4_18_2","unstructured":"Immune modulating therapies in pregnancy and lactation. https:\/\/www.acog.org\/clinical\/clinical-guidance\/committee-opinion\/articles\/2019\/04\/immune-modulating-therapies-in-pregnancy-and-lactation (accessed 7 November 2025)."},{"key":"e_1_3_4_19_2","unstructured":"Reproductive health in Rheumatic & Musculoskeletal Diseases Guideline. https:\/\/rheumatology.org\/reproductive-health-rheumatic-diseases-guideline (accessed 7 November 2025)."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-03113-0"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033251412477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033251412477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033251412477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:29:35Z","timestamp":1777678175000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033251412477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/09612033251412477"],"URL":"https:\/\/doi.org\/10.1177\/09612033251412477","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]}}}