{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:47:39Z","timestamp":1784238459888,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"UBA-CYT"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>(I) to study the association between antiphospholipid antibodies (aPL) and severe preeclampsia (PE) and (II) To assess the correlation between aPL and severe PE before and after 34 weeks of gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This prospective and interventional study included one hundred forty pregnant women separated in two groups based on their diagnostic status of PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Control Group<\/jats:title>\n                    <jats:p>Forty normal pregnant women beyond 20 weeks of pregnancy. Tested for aPL: during they obstetric control and followed until birth. We only included volunteers who completed pregnancy without pathologies and with a normal full-term new-born baby.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study group (SG)<\/jats:title>\n                    <jats:p>One hundred women with diagnosis of severe PE. Tested for aPL: at time of severe PE onset and followed until birth. We stratified SG according to weeks of gestation at the time of diagnosis of severe PE (early and late PE), cut-off point of 34 weeks.<\/jats:p>\n                    <jats:p>We compare the frequency of aPL positivity between control versus SG.<\/jats:p>\n                    <jats:p>We\u2019ve preformed two comparisons.<\/jats:p>\n                    <jats:p>a) Healthy Controls and patients with severe preeclampsia.<\/jats:p>\n                    <jats:p>b) In the study group comparison of early severe preeclampsia and late severe preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We compared the presence of aPL between Control 10.0% (4\/40) and SG 34.0% (34\/100). We found an association between severe PE and aPL positivity [OR = 4.63 (95% CI: 1.523 \u2013 14.107),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .005].\n                    <\/jats:p>\n                    <jats:p>\n                      We confirmed an association between early severe PE and the presence of aPL positivity [OR = 4384 (95% CI: 1.3615 \u2013 14.1206),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .01]. We also found an association between late severe PE and the presence of aPL positivity [OR = 5.0 (95% CI: 1.4901 \u2013 16.777),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .008].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that the presence of aPL is associated to severe PE. The positivity of aPL is associated to severity of PE, independently from gestational age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033251412481","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T15:57:20Z","timestamp":1766591840000},"page":"166-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the association between preeclampsia and antiphospholipid antibodies. A prospective study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-6240","authenticated-orcid":false,"given":"Beatriz","family":"Grand","sequence":"first","affiliation":[{"name":"University of Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Udry","sequence":"additional","affiliation":[{"name":"Research Center \u201cFundaci\u00f3n Respirar\u201d"},{"name":"Acute Hospital \u201cDr Carlos G. Durand\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Avigliano","sequence":"additional","affiliation":[{"name":"University of Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica Gonz\u00e1lez","family":"Alc\u00e1ntara","sequence":"additional","affiliation":[{"name":"University of Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Omar","family":"Latino","sequence":"additional","affiliation":[{"name":"Acute Hospital \u201cDr Carlos G. Durand\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Susana","family":"Voto","sequence":"additional","affiliation":[{"name":"University of Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"668","article-title":"Antiphospholipid syndrome: a comprehensive review of a complex and multisystemic disease","volume":"27","author":"Palomo I","year":"2009","unstructured":"Palomo I, Segovia F, Ortega C, et al. Antiphospholipid syndrome: a comprehensive review of a complex and multisystemic disease. 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