{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:43:06Z","timestamp":1792658586998,"version":"4.5.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lupus podocytopathy (LP) is an under-recognized pathological manifestation in patients with systemic lupus erythematosus (SLE). Despite being a distinct entity, current American College of Rheumatology (ACR)\/European Alliance of Associations for Rheumatology (EULAR) guidelines do not include specific recommendations about LP, contributing to uncertainty regarding its diagnosis and treatment. This systematic review aims to synthesize the available literature on LP from case reports, case series and retrospective cohort studies to better characterize its clinical course, thereby informing clinical decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A systematic search of EMBASE and MEDLINE was conducted to identify relevant studies. Eligible studies included case reports, case series, and cohort studies reporting SLE patients who had biopsy-proven lupus podocytopathy without features of class III, IV, or V lupus nephritis. Demographic characteristics, clinical presentations, relevant laboratory and pathology results, treatment and outcomes were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This systematic review included 26 studies (18 case reports\/small series and 8 cohorts), analyzing 19 individual cases and 240 cohort patients with LP. Most patients were young females, and LP was often part of the initial lupus manifestation with nephrotic-range proteinuria. Minimal change disease (MCD) was the predominant pathology. Patients with LP had an overall favorable outcome with treatment employing systemic steroid and steroid-sparing agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LP is an uncommon but distinct manifestation of SLE with overall favorable outcome with treatment using systemic steroid and steroid-sparing agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261415986","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:01:55Z","timestamp":1768276915000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Lupus podocytopathy: A systematic review of clinical evidence from cases and cohorts"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2387-0179","authenticated-orcid":false,"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"MetroHealth Medical Center"},{"name":"Case Western Reserve University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bismah","family":"Basharat","sequence":"additional","affiliation":[{"name":"MetroHealth Medical Center"},{"name":"Case Western Reserve University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefang","family":"Sun","sequence":"additional","affiliation":[{"name":"Rochester General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Subedi","sequence":"additional","affiliation":[{"name":"Georgetown\/Washington Hospital Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massiel","family":"Jimenez Artiles","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Ballou","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00398-2"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102871"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05780616"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38238"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01118-X"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.023"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.00350220141030"},{"issue":"7","key":"e_1_3_5_9_2","first-page":"835","article-title":"[A case report of lupus nephritis associated with minimal change nephrotic syndrome--comparison of various histological types of 67 cases with lupus nephritis]","volume":"34","author":"Okai T","year":"1992","unstructured":"Okai T, Soejima A, Suzuki M, et al. [A case report of lupus nephritis associated with minimal change nephrotic syndrome--comparison of various histological types of 67 cases with lupus nephritis]. Nihon Jinzo Gakkai Shi 1992; 34(7): 835\u2013840.","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP57120"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36875"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004050350"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06720615"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2019.08.011"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.10.017"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.169566"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V113413"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091340"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-024-01175-4"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13091"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0463-1"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"issue":"1","key":"e_1_3_5_23_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2023.09.002","article-title":"KDIGO 2024 clinical practice guideline for the management of LUPUS NEPHRITIS","volume":"105","author":"Kidney Disease Improving Global Outcomes KDIGO Lupus Nephritis Work Group","year":"2024","unstructured":"Kidney Disease Improving Global Outcomes KDIGO Lupus Nephritis Work Group. KDIGO 2024 clinical practice guideline for the management of LUPUS NEPHRITIS. Kidney Int 2024; 105(1s): S1\u2013s69.","journal-title":"Kidney Int"},{"key":"e_1_3_5_24_2","article-title":"American college of Rheumatology (ACR) guideline for the screening, treatment, and management of Lupus nephritis","author":"Sammaritano LR","year":"2024","unstructured":"Sammaritano LR, Askanase A, Bermas BL, et al. American college of Rheumatology (ACR) guideline for the screening, treatment, and management of Lupus nephritis. 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An unusual case of nephrotic range proteinuria in a short-standing type 1 diabetic patient with newly diagnosed systemic lupus erythematosus: a case report and literature review. Med Sci 2024; 12(4): 74.","journal-title":"Med Sci"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.5414\/CN109012"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0606-6"},{"issue":"5","key":"e_1_3_5_37_2","first-page":"57","article-title":"Lupus podocytopathy: a rare cause of nephrotic syndrome in patients with systemic lupus erythematosus","volume":"13","author":"Khan O","year":"2023","unstructured":"Khan O, Mohammadrezaei F, Aslam S, et al. Lupus podocytopathy: a rare cause of nephrotic syndrome in patients with systemic lupus erythematosus. 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