{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:19:47Z","timestamp":1790565587889,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 82060301"],"award-info":[{"award-number":["Grant No. 82060301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Over-activated Type I interferon (IFN-I) signaling has been widely documented in systemic lupus erythematosus (SLE), but the underlying mechanisms and role of IFN-inducible long noncoding RNAs (lncRNAs) are still being explored. Our study highlights LINC01410 as a novel IFN-\u03b1\u2013inducible lncRNA with potential contributions to SLE and LN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Human peripheral blood mononuclear cells (PBMCs) were collected from SLE patients and healthy donors. THP-1, HEK293\u00a0T, Jurkat T, and Raji B cell lines were treated with 1000\u00a0U\/mL IFN-\u03b1 to evaluate changes in LINC01410 expression. LINC01410 was further overexpressed in THP-1 cells to assess effects on cell proliferation, apoptosis, and macrophage polarization, coupled with measurements of cytokines IL-6 and TNF-\u03b1. Additionally, Western blot assays were performed to elucidate LINC01410-associated pathways and protein changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LINC01410 was found to be significantly upregulated in SLE PBMCs compared to healthy controls, and its expression was further elevated by IFN-\u03b1 stimulation in multiple immune cell lines and primary immune cells. Overexpression of LINC01410 in THP-1 cells promoted proliferation, inhibited apoptosis, and drove macrophage differentiation toward an M1 phenotype, with an increase in proinflammatory cytokines such as IL-6 and TNF-\u03b1. Enrichment analyses linked LINC01410 to several dysregulated immune processes, consistent with SLE\u2019s immunopathology. Cross-dataset validation revealed that LINC01410 modulates key miRNAs, including miR-34a-5p, miR-125a-3p, and miR-185-5p, via the competing endogenous RNA (ceRNA) mechanism, thereby exerting pivotal regulatory effects on critical pathways such as cell cycle regulation, adherens junction, and the PI3K-Akt signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reveal that LINC01410 is an IFN-I\u2013responsive lncRNA that contributes to hyperactive immunity in SLE by modulating monocyte\u2013macrophage function. LINC01410 may represent a novel biomarker and therapeutic target for overcoming disease flares and tissue damage associated with SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261416236","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:34:52Z","timestamp":1768916092000},"page":"352-365","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["LINC01410 is an IFN-I-inducible lncRNA that contributes to SLE pathogenesis by enhancing Monocyte\u2013Macrophage proliferation and inflammation"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-9723","authenticated-orcid":false,"given":"Qian","family":"Ma","sequence":"first","affiliation":[{"name":"Ningxia University"},{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"General Hospital of Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pu","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Huo","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dang","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00398-2"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02168-0"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02168-0"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169344"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1117"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.962393"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01607-8"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-021-01042-1"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02119-z"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03723-9"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02889-w"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102615"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf1970"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.05.025"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110530"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1237"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.179433"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101921-042422"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02043-2"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169344"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225445"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2022-222370"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.09.009"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071675"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111647"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.10.004"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070928"},{"key":"e_1_3_5_29_2","first-page":"534","article-title":"Anti-apolipoprotein A-1 autoantibodies correlate with disease activity in systemic lupus erythematosus","volume":"59","author":"Nigolian H","year":"2020","unstructured":"Nigolian H, Ribi C, Courvoisier DS, et al. 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