{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:50Z","timestamp":1777929230551,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease with frequent renal involvement. Although current remission induction therapies are effective, a high proportion of patients experience flares or are treatment-resistant. Combining immunosuppressants with Calcineurin Inhibitors (CNIs) may improve clinical response, but insufficient data exist for the Hispanic population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SLE and lupus nephritis (LN) with persistent proteinuria despite previous immunosuppression and who began a combined regimen, including CNIs, were included. 24-hour proteinuria and glomerular filtration rate (eGFR) as estimated by CKD-EPI were evaluated at 12 months and stratified by LN histological class.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      239 clinical records from patients with LN diagnosis were evaluated, and 42 met the inclusion criteria. At 12 months, complete and partial responses were reached by 26.2% and 35.7% of patients, respectively. Compared with baseline, a significant reduction in proteinuria was observed (2.89 vs 0.72\u00a0g\/d,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), and a transient decrease in eGFR was detected at 6 months (109 vs 104\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .001), which improved significantly at 12 months (109 vs 114\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For a Mexican cohort of patients with treatment-resistant lupus nephritis, the addition of CNIs can be effective. It achieves excellent biochemical response rates despite a transient reduction in eGFR that improves without treatment withdrawal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261416237","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:27:46Z","timestamp":1767914866000},"page":"272-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal efficacy of calcineurin inhibitors in treatment-resistant lupus nephritis: An experience among Mexican patients from a tertiary referral center"],"prefix":"10.1177","volume":"35","author":[{"given":"Irving Gast\u00f3n","family":"Ram\u00edrez-Santana","sequence":"first","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Alamilla-Sanchez","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Yanez-Salguero","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Gonz\u00e1lez-Fuentes","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn Benjam\u00edn","family":"Yam\u00e1-Estrella","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique Fleuvier","family":"Morales-L\u00f3pez","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Hopf-Estandia","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fani Guadalupe","family":"Ruiz-Rivera","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Horacio","family":"Cano-Cervantes","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Mat\u00edas-Carmona","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Manuel","family":"Flores-Garnica","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia","family":"Andrade-Ortega","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Canade","family":"Hern\u00e1ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-5658","authenticated-orcid":false,"given":"Juan Antonio","family":"Su\u00e1rez-Cuenca","sequence":"additional","affiliation":[{"name":"National Medical Center \u201c20 de Noviembre\u201d"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu158oa"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker101"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318786436"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac407"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000243"},{"issue":"4","key":"e_1_3_6_7_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","author":"Kidney Disease Improving Global Outcomes KDIGO Glomerular Diseases Work Group","year":"2021","unstructured":"Kidney Disease Improving Global Outcomes KDIGO Glomerular Diseases Work Group. 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