{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:12Z","timestamp":1777929192250,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Modifying iron metabolism to mitigate oxidative stress and rebalance the Th17\/Treg cell ratio in systemic lupus erythematosus (SLE) may represent a promising therapeutic target for treating SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      We used the iron chelator deferoxamine mesylate (DFO) and a low iron diet (LID) to treat imiquimod (IMQ)-induced lupus-like syndrome in mice. We observed the changes in T lymphocytes and iron metabolism in the spleen. Splenic naive CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells were induced to differentiate into Th17 and Treg cells through magnetic separation and were cultured with DFO solution to observe the effect of DFO on the balance of Th17\/Treg cells. Ras-selective lethal3 (RSL3)-induced ferroptosis in Na\u00efve CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells was treated with DFO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Major Findings<\/jats:title>\n                    <jats:p>We found that iron deficiency may promote the expansion of Treg cells and suppress the production of Th17 cells by activating the Nrf2\/HO-1\/GPX4 signaling pathway, reducing the accumulation of reactive oxygen species (ROS), and thus halting the progression of IMQ-induced lupus-like disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Iron deficiency, both\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      , inhibited the inflammatory response, reducing the production of inflammatory cytokines. This could present a possible therapeutic approach for SLE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261419990","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:44:25Z","timestamp":1769147065000},"page":"366-377","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron deficiency improves imiquimod-induced lupus-like disease by regulating the Th17\/Treg balance and Nrf2\/HO-1\/GPX4 signaling pathway"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3149-5514","authenticated-orcid":false,"given":"Yapeng","family":"Wang","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7403-9153","authenticated-orcid":false,"given":"Xinyue","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6904-8543","authenticated-orcid":false,"given":"Zexuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8269-7415","authenticated-orcid":false,"given":"Weipeng","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2334-3831","authenticated-orcid":false,"given":"Fugang","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-0767","authenticated-orcid":false,"given":"Jie","family":"Bao","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1025-1918","authenticated-orcid":false,"given":"Yongsheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2198-4178","authenticated-orcid":false,"given":"Guanqun","family":"Xie","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00544-4"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.186"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101921-042422"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102976"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102870"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100130"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102376"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01027"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.06.037"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094591"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05261-4"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4012"},{"key":"e_1_3_5_14_2","first-page":"103008","article-title":"Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis","volume":"20","author":"Liu YLX","year":"2023","unstructured":"Liu YLX, Chen Y, Dang J, et al. 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