{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:14:13Z","timestamp":1777929253040,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuropsychiatric systemic lupus erythematosus (NP-SLE) in children is uncommon but often severe, with a wide spectrum of neurologic presentations and sometimes atypical or initially normal neuroimaging. Among reported manifestations, acute cerebellitis is rare, and simultaneous thalamic involvement has scarcely been described. Differentiating inflammatory NP-SLE from mimics such as posterior reversible encephalopathy syndrome (PRES), infection, or ischemia is essential, since management strategies and prognosis differ substantially.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We describe a 13-year-old female with newly diagnosed SLE who developed acute cerebellitis accompanied by bilateral medial thalamic signal abnormalities and non-convulsive status epilepticus after extensive infectious and cerebrospinal fluid evaluation. MRI demonstrated cerebellar cortical diffusion restriction and faint bilateral thalamic T2-FLAIR\/DWI hyperintensity without corresponding ADC reduction, consistent with vasogenic edema, and without evidence of vascular occlusion. Management required high-dose corticosteroids, antiseizure therapy, plasmapheresis, cyclophosphamide, and rituximab. Her course was complicated by cytopenias, renal involvement, and encephalopathy, but she achieved gradual neurologic recovery with rehabilitation therapies and hydroxychloroquine maintenance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Simultaneous cerebellar and thalamic involvement expands the radiologic spectrum of pediatric NP-SLE and highlights thalamocerebellar network vulnerability underlying impaired consciousness. Recognition of this pattern supports early advanced MRI, continuous EEG monitoring, and prompt, multimodal immunotherapy to optimize outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261425757","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:39:24Z","timestamp":1770889164000},"page":"508-515","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent thalamic and cerebellar involvement in pediatric neuropsychiatric lupus: Expanding the radiologic spectrum"],"prefix":"10.1177","volume":"35","author":[{"given":"Jacob","family":"Anderson","sequence":"first","affiliation":[{"name":"Phoenix Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sareh","family":"Hosseinpour","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"},{"name":"Tehran University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"},{"name":"Tehran University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita","family":"Goswami","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Mangum","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute at Phoenix Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"T Karnik","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute at Phoenix Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Curran","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0440-5809","authenticated-orcid":false,"given":"Ali Reza","family":"Tavasoli","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"},{"name":"Barrow Neurological Institute at Phoenix Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40697"},{"issue":"1","key":"e_1_3_8_3_2","first-page":"OC05","article-title":"Neurological manifestations in systemic lupus erythematosus: a single centre study from North East India","volume":"11","author":"Kakati S","year":"2017","unstructured":"Kakati S, Barman B, Ahmed SU, et al. Neurological manifestations in systemic lupus erythematosus: a single centre study from North East India. J Clin Diagn Res: J Clin Diagn Res 2017; 11(1): OC05.","journal-title":"J Clin Diagn Res: J Clin Diagn Res"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3376-9"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3773-7"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308093071"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309356457"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1594210"},{"issue":"3","key":"e_1_3_8_9_2","first-page":"188","article-title":"Fulminant acute cerebellitis: an under-diagnosed condition","volume":"90","author":"Birlanga M","year":"2019","unstructured":"Birlanga M, Vila T. Fulminant acute cerebellitis: an under-diagnosed condition. InAnales de Pediatria 2019; 90(3): 188\u2013190.","journal-title":"InAnales de Pediatria"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2018.10.020"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12010070"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261425757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261425757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261425757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:29:46Z","timestamp":1777678186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261425757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/09612033261425757"],"URL":"https:\/\/doi.org\/10.1177\/09612033261425757","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}