{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:31:17Z","timestamp":1793323877061,"version":"4.5.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The dysfunction of interleukin-7 receptor alpha (IL-7R\u03b1), which is encoded by the\n                      <jats:italic toggle=\"yes\">IL7RA<\/jats:italic>\n                      gene, has been implicated in the development of systemic lupus erythematosus (SLE). This study aimed to investigate the relationship between two specific single-nucleotide polymorphisms (SNPs) in the\n                      <jats:italic toggle=\"yes\">IL7RA<\/jats:italic>\n                      gene\u2014rs6897932 (C&gt;T) and rs987106 (A&gt;T)\u2014and the risk of developing SLE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood samples were obtained from 105 Iranian individuals diagnosed with SLE and 105 healthy Iranian controls. The genotyping of these SNPs was carried out using the high-resolution melting (HRM) technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis using a dominant model revealed that the combined frequencies of the CT and TT genotypes for rs6897932 were associated with a decreased risk of SLE (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .009). Additionally, the T allele was found to be significantly less frequent in the patient cohort compared to the healthy controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005). Among laboratory parameters, C-reactive protein (CRP) levels were the only significant difference observed between patients with the CC genotype and those with CT or TT genotypes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007). In contrast, an assessment of various inheritance models for rs987106 did not indicate any significant association with SLE risk (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; .05), nor was there a statistically significant difference in the frequency of the T allele between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .434). However, the TT genotype of rs987106 was significantly correlated with elevated serum levels of anti-dsDNA antibodies and creatinine, as well as an increased number of patients displaying renal involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The findings suggest that the T allele of rs6897932 in the\n                      <jats:italic toggle=\"yes\">IL7RA<\/jats:italic>\n                      may provide a protective effect against the development of SLE. Although no significant association was found between rs987106 and SLE risk, it may still contribute to the disease\u2019s etiopathology, particularly concerning renal complications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261429135","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T15:50:48Z","timestamp":1771689048000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["rs6897932 (C&gt;T) and rs987106 (A&gt;T) variants in the\n                    <i>IL7RA<\/i>\n                    gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus"],"prefix":"10.1177","volume":"35","author":[{"given":"Faezeh","family":"Sarpeleh","sequence":"first","affiliation":[{"name":"Isfahan University of Medical 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