{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:14:48Z","timestamp":1777929288393,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM202411012"],"award-info":[{"award-number":["SZSM202411012"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20230807093803007"],"award-info":[{"award-number":["JCYJ20230807093803007"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To delineate immunophenotypic alterations associated with newly diagnosed childhood-onset systemic lupus erythematosus (cSLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peripheral blood from 25 newly diagnosed cSLE patients (ND-cSLEs) and 23 healthy controls (HCs) was examined by multiparameter flow cytometry to profile lymphocyte subsets and helper T-cell populations; serum cytokines were quantified by bead-based assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, ND-cSLEs exhibited cytopenias, reduced CD3\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells, a decreased CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD8\n                      <jats:sup>+<\/jats:sup>\n                      ratio, and diminished NK cells. Autoreactive CD21\n                      <jats:sup>-<\/jats:sup>\n                      CD27\n                      <jats:sup>-<\/jats:sup>\n                      B cells and plasmablasts were markedly expanded, whereas na\u00efve and memory B-cell compartments contracted. Both CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells demonstrated increased PD-1 and HLA-DR expression, indicating concurrent activation and exhaustion. T peripheral helper cells and CXCR3\n                      <jats:sup>+<\/jats:sup>\n                      Tfh cells were significantly enriched. Elevated serum IL-10, IL-8, and IL-21 levels further characterized the inflammatory milieu.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Newly Diagnosed cSLE patients is distinguished by profound remodeling of lymphocyte compartments, expansion of autoreactive and helper subsets, and heightened proinflammatory cytokine production, underscoring potential immunological biomarkers and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261429137","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:31:14Z","timestamp":1771875074000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic immune dysregulation: Expansion of autoreactive B cells and Tfh\/TPH cells and their clinical implications in childhood-onset lupus"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0198-2532","authenticated-orcid":false,"given":"Shu-Li","family":"Luo","sequence":"first","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Luo","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yao","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yan","family":"He","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4210-3510","authenticated-orcid":false,"given":"Xiao-Ying","family":"Fu","sequence":"additional","affiliation":[{"name":"Shantou University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(24)00172-X"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008086"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1335998"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39710"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2021.04.006"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.852162"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15836"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2022-0093"},{"key":"e_1_3_5_10_2","first-page":"70004","article-title":"MDSC-derived IFN-\u03b2 promotes T follicular helper cell response and exacerbates lupus development","volume":"28","author":"Rui K","year":"2025","unstructured":"Rui K, Chen Z, Liu J, et al. MDSC-derived IFN-\u03b2 promotes T follicular helper cell response and exacerbates lupus development. Arthritis Rheumatol 2025; 28: 70004. https:\/\/doi.org\/10.1002\/art.70004","journal-title":"Arthritis Rheumatol"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02297-2"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1208282"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147726"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003503"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_3_5_16_2","volume-title":"Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics","author":"Dai X","year":"2025","unstructured":"Dai X. Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics. 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