{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:16:07Z","timestamp":1790115367631,"version":"4.0.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the real-world safety, efficacy, and steroid-sparing effects of anifrolumab in patients with systemic lupus erythematosus (SLE) treated at a tertiary referral center in Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective observational study of all SLE\/discoid lupus patients who received at least one infusion of anifrolumab between May 2022 and February 2025 at Aarhus University Hospital. Clinical and laboratory data were extracted from electronic medical records at baseline, 3 months, 6 months, and last follow-up. Disease activity was assessed using SLEDAI-2K, Physician\u2019s Global Assessment (PGA), LLDAS, and DORIS criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-six patients (94% female, mean age 52 years) received anifrolumab for a mean of 462 days. Median SLEDAI-2K decreased from 8 at baseline to 2 at month 3, and to 0 at both month 6 and last follow-up. The proportion achieving SLEDAI-2K = 0 increased from 0% at baseline to 52% at both 6 months and last follow-up. At the last follow-up, 87% achieved both PGA \u22640.5 and LLDAS, while 70% achieved DORIS remission. Prednisolone doses declined by &gt;50%. Skin and musculoskeletal involvement showed the greatest improvement. Herpesvirus-related infections were the most frequent adverse events; two severe cases occurred, though treatment was generally continued.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anifrolumab was associated with rapid, sustained disease control and significant steroid-sparing effects. Herpesvirus infections were common, underscoring the importance of vaccination prior to treatment initiation. These findings support anifrolumab as an effective therapeutic option for SLE in routine clinical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261441397","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:34:24Z","timestamp":1775108064000},"page":"859-868","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Real-world use of anifrolumab in systemic lupus erythematosus: A retrospective study from a Danish tertiary center (2022\u20132025)"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4395-7121","authenticated-orcid":false,"given":"Laura","family":"N\u00f8rgaard","sequence":"first","affiliation":[{"name":"Aarhus University Hospital"},{"name":"Viborg Regional Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-0750","authenticated-orcid":false,"given":"Mads Lamm","family":"Larsen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent","family":"Deleuran","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Louise From","family":"Hermansen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-1268","authenticated-orcid":false,"given":"Anne","family":"Troldborg","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"},{"name":"Aarhus University"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151221"},{"key":"e_1_3_4_4_2","volume-title":"Systemic lupus erythematosus in adults: clinical manifestations and diagnosis","author":"Wallace DJ","year":"2025","unstructured":"Wallace DJ. Systemic lupus erythematosus in adults: clinical manifestations and diagnosis. Uptodate, 2025."},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.130124.erm"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207726"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209519"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.01.016"},{"key":"e_1_3_4_9_2","unstructured":"Agency EM. Saphnelo (anifrolumab). Available from: https:\/\/www.ema.europa.eu\/en\/documents\/overview\/saphnelo-epar-medicine-overview_en.pdf 2022."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1812201"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912196"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222748"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39962"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30076-1"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2020-000464"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/728zl6"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2024-0053"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2025.2528296"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead568"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.944505"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead348"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac491"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033241261746"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/rai2.70014"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00757-0"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-005076"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261441397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261441397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261441397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:30:00Z","timestamp":1780547400000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261441397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/09612033261441397"],"URL":"https:\/\/doi.org\/10.1177\/09612033261441397","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}