{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:48:25Z","timestamp":1782920905733,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate national and regional trends in age-standardized mortality rates (ASMRs) from childhood-onset systemic lupus erythematosus (cSLE) in Mexico between 2000 and 2023, stratified by sex and region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional, retrospective study used the INEGI national death registry via the Public Health Intelligence Unit (UISP-INSP). Deaths in children aged 1\u201314\u00a0years attributed to cSLE were identified using ICD-10 codes M32.1, M32.8, and M32.9, excluding M32.0. ASMRs per 100,000 population were calculated using the 2010 Mexican census as a reference. Trends by year, sex, and region were analyzed using Poisson regression models with log link and population offset. Incidence rate ratios (IRRs) with 95% confidence intervals were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2000 to 2023, 637 cSLE deaths were recorded among 280,334 child deaths. Females accounted for 80.4% (ASMR 0.13; 95% CI 0.12\u20130.15), nearly fourfold higher than males (0.03; 95% CI 0.03\u20130.04). Although the Central and Midwest regions concentrated over 60% of total deaths, ASMRs were similar across regions (range 0.08\u20130.09 per 100,000). No consistent temporal trend in mortality was observed. Poisson regression confirmed significantly lower mortality in boys compared to girls (IRR 0.24; 95% CI 0.19\u20130.29;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) with no statistically significant regional differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>cSLE mortality in Mexico has remained stable over time, with a marked female predominance. The regional distribution of deaths likely reflects population density rather than major differences in mortality risk. Strengthening early diagnosis, paediatric rheumatology care networks, and national surveillance systems is essential to reduce disease burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261445759","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:07:37Z","timestamp":1777018057000},"page":"965-971","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nationwide analysis of childhood-onset systemic lupus erythematosus mortality in Mexico, 2000\u20132023"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-4299","authenticated-orcid":false,"given":"Ivet","family":"Etchegaray-Morales","sequence":"first","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-7705","authenticated-orcid":false,"given":"Claudia","family":"Mendoza-Pinto","sequence":"additional","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla"},{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-7939","authenticated-orcid":false,"given":"Pamela","family":"Mungu\u00eda-Realpozo","sequence":"additional","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla"},{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1477-7884","authenticated-orcid":false,"given":"Diana","family":"Molina-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Survey and Evaluation Research Center, Instituto Nacional de Salud P\u00fablica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Eugenio","family":"Hern\u00e1ndez-\u00c1vila","sequence":"additional","affiliation":[{"name":"Survey and Evaluation Research Center, Instituto Nacional de Salud P\u00fablica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-3696","authenticated-orcid":false,"given":"Edith","family":"Ram\u00edrez-Lara","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-5875","authenticated-orcid":false,"given":"Alfonso Ragnar","family":"Torres-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Department, Hospital General del Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-2819","authenticated-orcid":false,"given":"\u00c1ngel David","family":"Osorio-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-0580","authenticated-orcid":false,"given":"Socorro","family":"M\u00e9ndez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40512"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-022-05154-9"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead519"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17994"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.09.005"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2023-1219"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211663"},{"key":"e_1_3_5_9_2","first-page":"554","article-title":"Trends and predictors of mortality in childhood onset lupus in a single North-Indian centre over 23 years: a retrospective study","volume":"34","author":"Abujam B","year":"2016","unstructured":"Abujam B, Gupta A, Suri D, et al. 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