{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:48:21Z","timestamp":1782920901799,"version":"3.54.5"},"reference-count":6,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-E-112218"],"award-info":[{"award-number":["TSGH-E-112218"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-E-113238"],"award-info":[{"award-number":["TSGH-E-113238"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-016-033"],"award-info":[{"award-number":["NSTC 112-2314-B-016-033"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-016-052-MY3"],"award-info":[{"award-number":["NSTC 114-2314-B-016-052-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A 66-year-old female with a 15-year history of refractory lupus nephritis, complicated by severe hypersplenism requiring splenectomy and 8\u00a0years of hemodialysis, successfully underwent deceased-donor kidney transplantation. Post-transplantation, she achieved an unprecedented, durable serological remission with a distinctive biphasic platelet recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To monitor her immune reconstitution, we performed longitudinal peripheral blood immunophenotyping, contextualized against an active systemic lupus erythematosus (SLE) cohort and an age-matched healthy control group to account for immunosenescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Notably, the B-cell repertoire maintained a persistently stable, low-end baseline of marginal zone B cells within the age-appropriate spectrum, reflecting the static legacy of her prior splenectomy. In sharp contrast to this static background, the T-cell compartment demonstrated a dynamic, within-subject V-shaped recovery of killer cell lectin-like receptor G1 + effector memory cytotoxic T cells (KLRG1 + EM Tc cells) from an active-disease baseline to age-appropriate healthy levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case illustrates that KLRG1 + effector memory cytotoxic T cell recovery is a signature of genuine immunological remission rather than mere aging or historical confounders, suggesting its potential as a precision biomarker for monitoring post-transplant immune stability in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261458567","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:14:03Z","timestamp":1780665243000},"page":"978-982","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep immunological resetting in refractory systemic lupus erythematosus post-kidney transplantation: A longitudinal immunophenotypic analysis"],"prefix":"10.1177","volume":"35","author":[{"given":"Ru-Fang","family":"Zheng","sequence":"first","affiliation":[{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"National Taiwan Ocean University"},{"name":"University of Copenhagen"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jung","family":"Ho","sequence":"additional","affiliation":[{"name":"National Defense Medical University"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Wen","family":"Lui","sequence":"additional","affiliation":[{"name":"Linkou Chang\u2010Gung Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wun-Long","family":"Jheng","sequence":"additional","affiliation":[{"name":"Hualien Tzu-Chi Hospital"},{"name":"Shizuoka Center for Molecular Intelligence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-8309","authenticated-orcid":false,"given":"Feng\u2010Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.70121"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom13060960"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033231160979"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.25259\/ijn_268_23"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI181034"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00494"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261458567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261458567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261458567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:14:04Z","timestamp":1782918844000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261458567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/09612033261458567"],"URL":"https:\/\/doi.org\/10.1177\/09612033261458567","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}